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Invitrogen
Pleiotrophin Monoclonal Antibody (851406)
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Product Details
MA5-61168
Product Specifications
Species Reactivity
Human
Host/Isotype
Rat
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
851406
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Pleiotrophin/PTN, Gly33-Asp168
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
Pleiotrophin (PTN) is an 18 kDa secreted heparin and chondroitin-binding protein that is a regulatory cytokine critical to the early development of blood vessels and neurons. High PTN serum levels are associated with a variety of solid tumors. It was shown that patients with multiple myeloma (MM) also have elevated serum levels of this protein. The expression of this protein is very limited in normal adult tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HB-GAM; HBBM; HBGF-8; HBNF; HBNF-1; heparin affin regulatory protein; Heparin-binding brain mitogen; Heparin-binding growth factor 8; Heparin-binding growth-associated molecule; heparin-binding neurite outgrowth promoting factor; Heparin-binding neurite outgrowth-promoting factor; Heparin-binding neurite outgrowth-promoting factor 1; OSF-1; Osteoblast-specific factor 1; Pleiotrophin; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1); PTN; unnamed protein product
Gene Aliases: HARP; HB-GAM; HBBM; HBGF-8; HBGF8; HBNF; HBNF-1; HBNF1; NEGF1; OSF-1; PTN
UniProt ID: (Human) P21246
Entrez Gene ID: (Human) 5764
ossification
leukocyte chemotaxis involved in inflammatory response
positive regulation of leukocyte chemotaxis
transmembrane receptor protein tyrosine phosphatase signaling pathway
integrin-mediated signaling pathway
nervous system development
negative regulation of neuroblast proliferation
learning
memory
positive regulation of cell proliferation
regulation of endothelial cell migration
positive regulation of neuron projection development
response to auditory stimulus
bone mineralization
positive regulation of bone mineralization
dendrite regeneration
regulation of myelination
tissue regeneration
receptor clustering
ossification involved in bone remodeling
estrous cycle
positive regulation of cell differentiation
positive regulation of ossification
decidualization
regulation of synaptic plasticity
oogenesis
positive regulation of axon regeneration
positive regulation of oligodendrocyte differentiation
modulation of synaptic transmission
positive regulation of cell division
dendrite arborization
positive regulation of dendrite development
negative regulation of long-term synaptic potentiation
regulation of hemopoiesis
regulation of stem cell population maintenance
positive regulation of hepatocyte proliferation
positive regulation of stem cell differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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