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Invitrogen
NUDT5 Monoclonal Antibody (739044)
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Product Details
MA5-61664
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
739044
Immunogen
E. coli-derived recombinant human ADP-Sugar Pyrophosphatase/NUDT5, Glu2-Phe219
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 8-oxo-dGDP phosphatase; ADP-sugar pyrophosphatase; Nuclear ATP-synthesis protein NUDIX5; Nucleoside diphosphate-linked moiety X motif 5; nudix (nucleoside diphosphate linked moiety X)-type motif 5; nudix hydrolase; Nudix motif 5; NUDT5; unnamed protein product; YSA1H
Gene Aliases: hNUDT5; HSPC115; NUDIX5; NUDT5; YSA1; YSA1H; YSAH1
UniProt ID: (Human) Q9UKK9
Entrez Gene ID: (Human) 11164
magnesium ion binding
RNA binding
protein binding
transferase activity
nucleotidyltransferase activity
hydrolase activity
nucleoside-diphosphatase activity
ADP-sugar diphosphatase activity
snoRNA binding
identical protein binding
protein homodimerization activity
8-oxo-dGDP phosphatase activity
metal ion binding
ADP-ribose diphosphatase activity
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
nucleobase-containing compound metabolic process
chromatin remodeling
nucleoside phosphate metabolic process
nucleotide metabolic process
ribonucleoside diphosphate catabolic process
D-ribose catabolic process
ribose phosphate metabolic process
nucleobase-containing small molecule metabolic process
ATP generation from poly-ADP-D-ribose
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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