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Invitrogen
C/EBP alpha Monoclonal Antibody (692716)
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Product Details
MA5-61762
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
692716
Immunogen
E. coli-derived recombinant human CEBP alpha , Met1-Ala124
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP. One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation. From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C EBP; C/EBP alpha; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer-binding protein alpha; OTTHUMP00000220269
Gene Aliases: C/EBP-alpha; CEBP; CEBPA
UniProt ID: (Human) P49715
Entrez Gene ID: (Human) 1050
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase I regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
kinase binding
protein domain specific binding
chromatin DNA binding
identical protein binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
macromolecular complex binding
protein heterodimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
HMG box domain binding
STAT family protein binding
DNA-binding transcription factor binding
urea cycle
negative regulation of transcription from RNA polymerase II promoter
liver development
embryonic placenta development
epithelial cell maturation
osteoblast development
generation of precursor metabolites and energy
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase I promoter
acute-phase response
mitochondrion organization
Notch signaling pathway
response to nutrient
memory
cholesterol metabolic process
cell proliferation
negative regulation of cell proliferation
positive regulation of gene expression
cytokine-mediated signaling pathway
myeloid cell differentiation
cell differentiation
macrophage differentiation
lung development
granulocyte differentiation
organ regeneration
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
response to vitamin B2
regulation of cell proliferation
glucose homeostasis
positive regulation of macrophage activation
fat cell differentiation
positive regulation of fat cell differentiation
positive regulation of osteoblast differentiation
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
inner ear development
positive regulation of inflammatory response
white fat cell differentiation
brown fat cell differentiation
regulation of cell cycle
lipid homeostasis
interleukin-6-mediated signaling pathway
white fat cell proliferation
cellular response to lithium ion
cellular response to tumor necrosis factor
hematopoietic stem cell proliferation
cellular response to xenobiotic stimulus
response to dexamethasone
response to phenylpropanoid
energy homeostasis
integrated stress response signaling
negative regulation of hematopoietic stem cell proliferation
positive regulation of DNA-templated transcription, initiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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