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Dectin 1 Monoclonal Antibody (15E2), APC

View all (32) Dectin 1 (Clec7a) antibodies

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Dectin 1 Monoclonal Antibody (15E2), APC

Product Details

MA562304

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

10 µL/100 µL whole blood or 10^6 cells
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

15E2

Immunogen

Extracellular part of human CD369 with hIgG FC tag.
3D Epitope / Immunogen

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra spectra

Form

Liquid

Concentration

0.02 mg/mL

Purification

Size-exclusion chromatography

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

15mM sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3703490

Target Information

CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Beta-glucan receptor; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin BGRA; C-type lectin BGRB; C-type lectin BGRC; C-type lectin BGRD; C-type lectin BGRE; C-type lectin BGRF; C-type lectin BGRG; C-type lectin BGRH; C-type lectin domain family 7 member A; C-type lectin superfamily member 12; CD369; DC-associated C-type lectin 1; dectin-1; dectin-1 beta; dectin-1; C-type lectin receptor; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1; unnamed protein product

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Gene Aliases: BGR; CANDF4; CD369; CLEC7A; CLECSF12; DECTIN1; SCARE2; UNQ539/PRO1082

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UniProt ID: (Human) Q9BXN2

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Entrez Gene ID: (Human) 64581

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Function(s)
(1->3)-beta-D-glucan binding protein binding carbohydrate binding pattern recognition receptor activity MHC protein binding identical protein binding metal ion binding
Process(es)
cell activation response to yeast detection of yeast stimulatory C-type lectin receptor signaling pathway immune system process positive regulation of cytokine production involved in immune response positive regulation of dendritic cell cytokine production cell surface pattern recognition receptor signaling pathway phagocytosis, recognition inflammatory response cell recognition positive regulation of cell proliferation carbohydrate mediated signaling positive regulation of gene expression detection of fungus positive regulation of cell migration positive regulation of protein complex assembly detection of molecule of fungal origin positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-2 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of superoxide anion generation T cell activation defense response to protozoan regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade innate immune response leukocyte activation positive regulation of nitric oxide biosynthetic process positive regulation of phagocytosis positive regulation of calcium-mediated signaling positive regulation of lymphocyte activation positive regulation of respiratory burst antifungal innate immune response regulation of calcineurin-NFAT signaling cascade positive regulation of calcineurin-NFAT signaling cascade cellular response to molecule of fungal origin positive regulation of monocyte chemotactic protein-1 production positive regulation of wound healing apoptotic signaling pathway positive regulation of cytokine production involved in inflammatory response positive regulation of cell maturation positive regulation of T-helper 17 type immune response
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