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Invitrogen
FKBP4 Recombinant Rabbit Monoclonal Antibody (K01_1R21)
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Product Details
MA563370
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Hamster,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
K01_1R21
Immunogen
A synthetic peptide of human FKBP52.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
50mM tris glycine, pH 7.4, with 0.05% BSA, 150mM NaCl, 40% glycerol
Contains
0.01% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
FKBP4, encoding FK506-binding protein 4, is part of the immunophilin family and plays roles in cellular processes like protein folding and trafficking. The FKBP4 gene is located on chromosome 12, where it encodes a protein involved in modulating the androgen receptor signaling pathway and has been implicated in various cancers, including non-small-cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC). Structural variants of FKBP4 found through exome sequencing have shown potential deleterious effects on protein function. This gene is associated with cell proliferation, apoptosis, migration, and invasion in cancer cells. FKBP4 also influences metabolic processes, such as glycolysis, thereby contributing to cancer cell survival and growth. Importantly, FKBP4 has a role in disorders of sexual development due to its regulatory interaction with hormone signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 51 kDa FK506-binding protein; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 4, 59kDa; FK506 binding protein 52; FK506-binding protein 4; FKBP-4; FKBP51; FKBP52 protein; FKBP59; HBI; HSP binding immunophilin; HSP-binding immunophilin; Immunophilin FKBP52; p59; Peptidyl-prolyl cis-trans isomerase FKBP4; peptidylprolyl cis-trans isomerase; PPIase FKBP4; Rotamase; T-cell FK506-binding protein, 59kD; unnamed protein product
Gene Aliases: 59kDa; AL022792; AW208983; FKBP-4; FKBP-52; FKBP4; FKBP51; FKBP52; FKBP59; FKPB52; HBI; Hsp56; I79_001345; p52; p59; PPIase
UniProt ID: (Human) Q02790, (Mouse) P30416, (Rat) Q9QVC8
Entrez Gene ID: (Human) 2288, (Mouse) 14228, (Chinese hamster) 100762395, (Rat) 260321
RNA binding
peptidyl-prolyl cis-trans isomerase activity
protein binding
ATP binding
GTP binding
FK506 binding
isomerase activity
protein binding, bridging
heat shock protein binding
copper-dependent protein binding
glucocorticoid receptor binding
tau protein binding
phosphoprotein binding
poly(A) RNA binding
chaperone
protein folding
steroid hormone receptor complex assembly
copper ion transport
embryo implantation
negative regulation of neuron projection development
androgen receptor signaling pathway
prostate gland development
negative regulation of microtubule polymerization or depolymerization
negative regulation of microtubule polymerization
protein complex localization
male sex differentiation
reproductive structure development
protein peptidyl-prolyl isomerization
chaperone-mediated protein folding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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