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Invitrogen
MiTF Recombinant Rabbit Monoclonal Antibody (K01_1T90)
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Product Details
MA563702
Product Specifications
Species Reactivity
Hamster,
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
K01_1T90
Immunogen
Recombinant protein of human MiTF.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
50mM tris glycine, pH 7.4, with 40% glycerol, 150mM NaCl, 0.05% BSA
Contains
0.01% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Mi is a basic helix-loop-helix-leucine zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells and bone development. The mutation of Mi causes Waardenburg Syndrome type II in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of Mi differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52 kDa and 56 kDa, while the longer Mi form runs as a cluster of bands at 60-70 kDa in osteoclasts and in B16 melonoma cells (but not other melanoma cell lines), as well as mast cells and heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHe32; Class E basic helix-loop-helix protein 32; melanogenesis associated transcription factor; microphtalmia-associated transcription factor; microphthalmia; Microphthalmia-associated transcription factor; unnamed protein product
Gene Aliases: BHLHE32; CMM8; COMMAD; I79_000367; MI; MITF; MITF-A; WS2; WS2A
UniProt ID: (Human) O75030
Entrez Gene ID: (Human) 4286, (Chinese hamster) 100754846
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein dimerization activity
E-box binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
regulation of gene expression
positive regulation of gene expression
Wnt signaling pathway
cell differentiation
osteoclast differentiation
melanocyte differentiation
negative regulation of cell migration
regulation of cell proliferation
camera-type eye development
negative regulation of apoptotic process
pigmentation
cell fate commitment
regulation of osteoclast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
bone remodeling
protein-containing complex assembly
melanocyte apoptotic process
positive regulation of DNA-templated transcription, initiation
regulation of RNA biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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