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Invitrogen
TIAM2 Recombinant Rabbit Monoclonal Antibody (K01_2J29)
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Product Details
MA563869
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
K01_2J29
Immunogen
Recombinant protein of human TIAM2.
Conjugate
Form
Liquid
Concentration
1.10 mg/mL
Amount
110 µg
Purification
Protein A/G
Storage buffer
50mM tris glycine, pH 7.4, with 40% glycerol, 150mM NaCl, 0.05% BSA
Contains
0.01% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Rho guanine nucleotide exchange factor TIAM2; SIF and TIAM1-like exchange factor; similar to TIAM1; STEF; T cell lymphoma invasion and metastasis 2; T-lymphoma invasion and metastasis-inducing protein 2; TIAM-2; unnamed protein product
Gene Aliases: KIAA2016; STEF; TIAM-2; TIAM2
UniProt ID: (Human) Q8IVF5
Entrez Gene ID: (Human) 26230
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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