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Invitrogen
TRIF Recombinant Rabbit Monoclonal Antibody (K01_2J54)
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Product Details
MA563891
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
K01_2J54
Immunogen
Recombinant protein of human TRIF.
Conjugate
Form
Liquid
Concentration
0.60 mg/mL
Amount
60 µg
Purification
Protein A/G
Storage buffer
50mM tris glycine, pH 7.4, with 40% glycerol, 0.05% BSA, 150mM NaCl
Contains
0.01% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hCG_39321; HSD34; MyD88-3; Proline-rich, vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; RNF36; TI; TICAM-1; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adaptor inducing interferon-beta; toll like receptor adaptor molecule 1; toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; toll-like receptor adaptor molecule 1
Gene Aliases: AW046014; AW547018; IIAE6; MyD88-3; PRVTIRB; TICAM-1; TICAM1; TRIF
UniProt ID: (Human) Q8IUC6, (Mouse) Q80UF7
Entrez Gene ID: (Human) 148022, (Mouse) 106759, (Rat) 363328
toll-like receptor signaling pathway
macrophage activation involved in immune response
immune system process
positive regulation of myeloid dendritic cell cytokine production
MyD88-independent toll-like receptor signaling pathway
nitric oxide biosynthetic process
apoptotic process
inflammatory response
signal transduction
cell surface receptor signaling pathway
positive regulation of autophagy
positive regulation of gene expression
positive regulation of B cell proliferation
positive regulation of protein ubiquitination
lipopolysaccharide-mediated signaling pathway
positive regulation of type I interferon production
response to lipopolysaccharide
positive regulation of chemokine production
positive regulation of interferon-beta production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of natural killer cell activation
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
B cell proliferation
B cell activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of protein complex assembly
response to exogenous dsRNA
innate immune response
positive regulation of nitric oxide biosynthetic process
positive regulation of B cell activation
defense response to virus
positive regulation of macrophage cytokine production
cellular response to lipopolysaccharide
apoptotic signaling pathway
cellular response to oxidised low-density lipoprotein particle stimulus
positive regulation of cytokine production involved in inflammatory response
positive regulation of protein binding
regulation of protein homodimerization activity
positive regulation of chemokine biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of NF-kappaB transcription factor activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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