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Invitrogen
Ubiquitin B Recombinant Rabbit Monoclonal Antibody (K01_2J78)
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FIGURE: 1 / 2
Ubiquitin B Antibody (MA563910) in IHC (P)
Immunohistochemistry (Paraffin) analysis of Ubiquitin B in paraffin-embedded Human colon cancer. Samples were incubated with Ubiquitin B recombinant monoclonal (Product # MA563910). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
Product Details
MA563910
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
K01_2J78
Immunogen
A synthetic peptide of human Ubiquitin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
50mM tris glycine, pH 7.4, with 40% glycerol, 0.05% BSA, 150mM NaCl
Contains
0.01% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Ubiquitin is a highly conserved protein of about 8.5 kDa molecular weight, which has an ATP dependent role in the targeting of proteins for proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C terminus of ubiquitin, and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions, which appear to be resistant to normal degradation. Therefore, ubiquitin antibodies are very useful for studies of these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease are all heavily ubiquitinated and can be readily visualized with ubiquitin antibodies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory protein Li 50; HUBCEP52; MGC127041; polyubiquitin B; Polyubiquitin-B; RPL40; unnamed protein product
Gene Aliases: HEL-S-50; UBB
UniProt ID: (Human) P0CG47
Entrez Gene ID: (Human) 7314
male meiosis I
female meiosis I
male gonad development
female gonad development
protein ubiquitination
modification-dependent protein catabolic process
hypothalamus gonadotrophin-releasing hormone neuron development
positive regulation of protein ubiquitination
regulation of neuron apoptotic process
mitochondrion transport along microtubule
neuron projection morphogenesis
regulation of mitochondrial membrane potential
adipose tissue development
fat pad development
regulation of proteasomal protein catabolic process
seminiferous tubule development
energy homeostasis
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of protein monoubiquitination
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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