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Invitrogen
Metadherin Recombinant Rabbit Monoclonal Antibody (K01_2N15)
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Product Details
MA564115
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
K01_2N15
Immunogen
Recombinant protein of human LYRIC/AEG1 (aa 214-440).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
50mM tris glycine, pH 7.4, with 40% glycerol, 0.05% BSA, 150mM NaCl
Contains
0.01% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SGSLDSTIPG IENTITVTTE QLTTASFPVG SKKNKGDSHL NVQVSNFKSG KGDSTLQVSS GLNENLTVNG GGWNEKSVKL SSQISAGEEK WNSVSPASAG KRKTEPSAWS QDTGDANTNG KDWGRSWSDR SIFSGIGSTA EPVSQSTTSD YQWDVSRNQP YIDDEWSGLN GLSSADPNSD WNAPAEEWGN WVDEERASLL KSQEPIPDDQ KVSDDDKEKG EGALPTG
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%, Pig - 95%, Cynomolgus monkey - 99%.
Target Information
Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3D3/LYRIC; AEG-1; astrocyte elevated gene 1; Astrocyte elevated gene-1 protein; LYRIC/ MTDH; Lysine-rich CEACAM1 co-isolated protein; lysine-rich protein; Metadherin; Metastasis adhesion protein; Protein LYRIC; putative CEACAM1 associated protein; putative membrane-bound GTPase
Gene Aliases: 3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3; MTDH
UniProt ID: (Human) Q05DH2
Entrez Gene ID: (Human) 92140
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
positive regulation of autophagy
lipopolysaccharide-mediated signaling pathway
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein kinase B signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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