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Invitrogen

HSPA1B Recombinant Rabbit Monoclonal Antibody (K01_2U22)

View all (26) HSPA1B antibodies

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Product Details

MA564278

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

K01_2U22

Immunogen

Recombinant protein of mouse Hsp70.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

50mM tris glycine, pH 7.4, with 40% glycerol, 0.05% BSA, 150mM NaCl

Contains

0.01% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3705326

Target Information

This intronless gene encodes a 70 kDa heat shock protein which is a member of the heat shock protein 70 family. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 68 kDa heat shock protein; Heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; heat shock 70kD protein 1B; heat shock 70kDa protein 1B; Heat shock protein; heat shock protein 70.1; Heat shock protein family A member 1A; Heat shock protein family A member 1B; heat shock protein, 70 kDa 1; HSP; HSP70-1; HSP70-1/HSP70-2; HSP70-1A; HSP70-2; HSP70.1; HSP70.1/HSP70.2; HSP70I; unnamed protein product

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Gene Aliases: Hcp70.1; hsp68; Hsp70; HSP70-1; HSP70-1B; HSP70-2; HSP70.1; HSP70.2; Hsp70a1; HSP72; HSPA1; HSPA1A; HSPA1B; Hspa2; HSX70

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UniProt ID: (Human) P0DMV8, (Mouse) P17879

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Entrez Gene ID: (Human) 3304, (Mouse) 15511, (Rat) 294254

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Function(s)
nucleotide binding virus receptor activity G-protein coupled receptor binding RNA binding receptor binding protein binding ATP binding ATPase activity enzyme binding heat shock protein binding ubiquitin protein ligase binding histone deacetylase binding protein binding involved in protein folding unfolded protein binding C3HC4-type RING finger domain binding ATP-dependent protein disaggregase activity ATP-dependent protein folding chaperone molecular_function double-stranded RNA binding ATPase activity, coupled poly(A) RNA binding protein N-terminus binding
Process(es)
binding of sperm to zona pellucida response to heat negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process telomere maintenance response to ischemia DNA repair mRNA catabolic process response to unfolded protein negative regulation of cell proliferation response to radiation response to mechanical stimulus regulation of cell death neuron differentiation negative regulation of cell growth negative regulation of protein ubiquitination cellular response to heat protein refolding response to ethanol positive regulation of erythrocyte differentiation positive regulation of neuron differentiation negative regulation of cell death cellular heat acclimation negative regulation of inclusion body assembly negative regulation of extrinsic apoptotic signaling pathway in absence of ligand protein folding positive regulation of gene expression regulation of protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of interleukin-8 production cellular response to oxidative stress ATP metabolic process viral entry into host cell protein stabilization positive regulation of NF-kappaB transcription factor activity positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to steroid hormone stimulus positive regulation of microtubule nucleation regulation of mitotic spindle assembly positive regulation of tumor necrosis factor-mediated signaling pathway
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