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Invitrogen
PPARGC1B Recombinant Rabbit Monoclonal Antibody (K01_3K02)
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Product Details
MA564324
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
K01_3K02
Immunogen
Peptide.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
50mM tris glycine, pH 7.4, with 40% glycerol, 150mM NaCl, 0.05% BSA
Contains
0.01% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ERR ligand 1; PERC; PERC-s; lacks one estrogen receptor interaction domain; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; pgc-1 beta; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC-1beta; PGC-1beta/ERRL1; PGC1beta-1a; PGC1beta-1b; PGC1beta-2a; PGC1beta-2b; PPAR gamma coactivator-1beta protein; PPAR-gamma coactivator 1-beta; PPARAGCIbeta; PPARgamma coactivator 1 beta; PPARGC-1-beta; unnamed protein product
Gene Aliases: 4631412G21Rik; ERRL1; PERC; PGC-1(beta); PGC1; PGC1B; PGC1beta; PPARGC1; PPARGC1B
UniProt ID: (Human) Q86YN6, (Rat) Q811R2, (Mouse) Q8VHJ7
Entrez Gene ID: (Human) 133522, (Rat) 291567, (Mouse) 170826
nucleic acid binding
transcription cofactor activity
transcription coactivator activity
RNA binding
protein binding
estrogen receptor binding
AF-2 domain binding
nucleotide binding
RNA polymerase II transcription cofactor activity
molecular_function
transcription factor binding
ligand-dependent nuclear receptor transcription coactivator activity
receptor activator activity
transcription cofactor
regulation of transcription, DNA-templated
intracellular estrogen receptor signaling pathway
positive regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
energy homeostasis
positive regulation of cold-induced thermogenesis
ossification
transcription from RNA polymerase II promoter
transcription from mitochondrial promoter
actin filament organization
positive regulation of alkaline phosphatase activity
cellular response to reactive oxygen species
positive regulation of phosphorylation
positive regulation of bone resorption
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of sequence-specific DNA binding transcription factor activity
response to glucocorticoid
response to cAMP
bone trabecula formation
positive regulation of receptor activity
transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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