Search

  • Order Status
  • Quick Order

Invitrogen

IL-12 p40 Monoclonal Antibody (C2)

View all (34) IL-12 p40 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
IL-12 p40 Monoclonal Antibody (C2)

Product Details

MA566046

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5-20 µg/mL
-

Immunocytochemistry (ICC/IF)

5-20 µg/mL
-
Product Specifications

Species Reactivity

Human, Pig, Rat

Host/Isotype

Mouse / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

C2

Immunogen

Recombinant Interleukin 12B (IL12B) (Val30-Ser320)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3715194

Target Information

IL12B (IL-12 p40) encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kDa cytokine receptor like subunit encoded by this gene, and a 35 kDa subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: CLMF p35; CLMF p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 subunit p35; IL-12 subunit p40; IL-12A; IL-12B; IL12; IL12 p40; IL12, subunit p40; IL12A; Interleukin; interleukin 12, p40; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 beta chain; interleukin-12 p40; interleukin-12 p40 subunit; Interleukin-12 subunit beta; interleukin-23 p40 subunit; natural killer cell stimulatory factor 2; cytotoxic lymphocyte maturation factor 2; IL12p40; natural killer cell stimulatory factor, 40 kD subunit; NK cell stimulatory factor chain 2; NKSF/CLMF; IL12p40; 40kD; NKSF1; NKSF2; RP23-388G23.1

View more View less

Gene Aliases: CLMF; CLMF2; IL-12B; Il12; IL12B; IMD28; IMD29; NKSF; NKSF2

View more View less

UniProt ID: (Human) P29460, (Pig) Q28938

View more View less

Entrez Gene ID: (Human) 3593, (Pig) 397076, (Rat) 64546

View more View less

Function(s)
cytokine receptor activity cytokine activity cytokine receptor binding interleukin-12 receptor binding protein binding growth factor activity interleukin-12 alpha subunit binding identical protein binding macromolecular complex binding interleukin-23 receptor binding protein heterodimerization activity protein homodimerization activity transmembrane signal receptor
Process(es)
regulation of cytokine production positive regulation of leukocyte mediated cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of defense response to virus by host natural killer cell activation involved in immune response positive regulation of lymphocyte mediated immunity positive regulation of T-helper 1 type immune response positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of inflammatory response to antigenic stimulus cell surface receptor signaling pathway JAK-STAT cascade cell proliferation response to UV-B cell migration natural killer cell activation negative regulation of interleukin-10 production negative regulation of interleukin-17 production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell activation positive regulation of natural killer cell proliferation positive regulation of mononuclear cell proliferation positive regulation of tissue remodeling positive regulation of smooth muscle cell apoptotic process interleukin-12-mediated signaling pathway T-helper 1 type immune response T-helper cell differentiation T cell proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation T cell activation defense response to protozoan positive regulation of memory T cell differentiation T-helper 1 cell differentiation positive regulation of osteoclast differentiation positive regulation of cell adhesion oocyte development negative regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation negative regulation of protein secretion regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium positive regulation of NK T cell activation positive regulation of NK T cell proliferation defense response to virus cellular response to lipopolysaccharide cellular response to interferon-gamma negative regulation of vascular endothelial growth factor signaling pathway positive regulation of NIK/NF-kappaB signaling negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of T-helper 17 type immune response positive regulation of T-helper 17 cell lineage commitment cell cycle arrest positive regulation of activation of Janus kinase activity T-helper 1 cell cytokine production positive regulation of tyrosine phosphorylation of STAT protein positive regulation of activation of JAK2 kinase activity cytokine-mediated signaling pathway sensory perception of pain regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of tyrosine phosphorylation of Stat4 protein positive regulation of tyrosine phosphorylation of Stat5 protein negative regulation of growth of symbiont in host
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support