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Invitrogen
alpha-1 Antitrypsin Monoclonal Antibody (TMF1#4B5)
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FIGURE: 1 / 5
alpha-1 Antitrypsin Antibody (MIA1101) in ICC/IF
Immunofluorescent analysis of Alpha1-Antitrypsin was performed using 70% confluent log phase Hep G2 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Alpha1-Antitrypsin (TMF1#4B5) Mouse Monoclonal Antibody (Product # MIA1101) at 2 µg/mL in 0.1% BSA and ... View More
Product Details
MIA1101
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
TMF1#4B5
Immunogen
Purified human a1-Antitrypsin
Conjugate
Form
Liquid
Concentration
5 mg/mL
Amount
1 mg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MIA1101 targets Alpha1-Antitrypsin in IP applications and shows reactivity with Human samples.
The MIA1101 immunogen is purified human a1-Antitrypsin.
MIA1101 detects Alpha1-Antitrypsin which has a predicted molecular weight of approximately 46 kDa.
MIA1101 was formerly sold as a Seradyn product.
Target Information
Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a-1 AT; a1-antitrypsin; alpha 1 antitrypsin; alpha-1 antitrypsin; Alpha-1 protease inhibitor; alpha-1 proteinase inhibitor; Alpha-1-antiproteinase; Alpha-1-antitrypsin; alpha-1-antitrypsin (alpha-1-AT); anti-elastase; Digestive Zymogen; epididymis secretory sperm binding protein; MGC23330; MGC9222; protease inhibitor; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; Protease Serine 1; proteolytic enzyme inhibitor; serine (or cysteine) proteinase inhibitor, clade A, member 1; Serine Protease 1; Serpin A1; serpin peptidase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 1 isoform SERPINA1_1; serpin peptidase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 1 isoform SERPINA1_2; serpin peptidase inhibitor clade A (alpha-1antiproteinase, antitrypsin) member 1; serpin peptidase inhibitor clade A member 1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; TRP1; TRY1; unnamed protein product
Gene Aliases: A1A; A1AT; AAT; alpha1AT; nNIF; PI; PI1; PRO0684; PRO2209; PRO2275; SERPINA1
UniProt ID: (Human) P01009
Entrez Gene ID: (Human) 5265
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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