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Invitrogen
Human DR3 (residues 398-417) Synthetic Peptide
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Product Details
OPEP-01002
Product Specifications
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
50 µg
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
OPEP-01002 can be used as a blocking peptide with polyclonal antibody PA5-19866.
Target Information
DR3/TNFRSF25 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of DR3/TNFRSF25 in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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