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Invitrogen

ADORA1 Polyclonal Antibody

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View all (15) ADORA1 antibodies

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ADORA1 Polyclonal Antibody

Product Details

PA1-041A

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
View 6 publications 6 publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

2 µg/mL
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues C(309) Q P K P P I D E D L P E E K A E D(326) of rat Adenosine Receptor A1.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2222233

Product Specific Information

PA1-041A detects adenosine receptor A1 (A1AR) in rat tissues. This antibody does not detect other AR subtypes. Previous lots of this antibody have been used in human and bovine samples.

PA1-041A has been successfully used in Immunohistochemistry (paraffin) and Western blot procedures. By Western blot, this antibody detects an ~37 kDa protein in rat brain representing A1AR.

The PA1-041A immunogen is a synthetic peptide corresponding to residues C(309) Q P K P P I D E D L P E E K A E D(326) of rat Adenosine Receptor A1.

Target Information

Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical and pharmacological analyses of the AR genes and protein has led to the discovery of four distinct AR subtypes (A1, A2a, A2b, A3). Activation of ARs mediates several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission. The A1AR is a glycoprotein that can activate Gi and Go proteins in vitro. In intact cells, agonist occupation of the A1AR has been shown to cause pertussis toxin-sensitive inhibition of adenylyl cyclase activity and, in some systems, a stimulation of phospholipase C resulting in mobilization of intracellular calcium stores. Activation of potassium channels by A1AR has been intensively studied in relation to its dramatic effects on the cardiovascular system. A1AR protein is highly expressed in brain (especially cerebellum, hippocampus, thalamus, and cortex) and spinal cord and in part, modulates neurotransmitter release. In white adipocytes A1AR inhibits lipolysis and stimulates glucose uptake. Other tissues also express A1AR including kidney and testis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Adenosine receptor A1; adenylate cyclase inhibitor; ADO-A1 receptor; ADORA1; AR; lacks the N-terminus and first three transmembrane domains; lacks the N-terminus and the first three transmembrane domains; unnamed protein product

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Gene Aliases: ADORA1; RDC7

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UniProt ID: (Human) P30542, (Rat) P25099

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Entrez Gene ID: (Human) 134, (Rat) 29290

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Function(s)
G-protein coupled adenosine receptor activity G-protein coupled receptor binding purine nucleoside binding G-protein coupled receptor activity protein binding heat shock protein binding G-protein beta/gamma-subunit complex binding heterotrimeric G-protein binding macromolecular complex binding protein heterodimerization activity phospholipase C activity G-protein coupled receptor
Process(es)
temperature homeostasis response to hypoxia adenosine receptor signaling pathway regulation of respiratory gaseous exchange by neurological system process negative regulation of acute inflammatory response negative regulation of leukocyte migration positive regulation of peptide secretion positive regulation of systemic arterial blood pressure negative regulation of systemic arterial blood pressure regulation of glomerular filtration protein targeting to membrane phagocytosis inflammatory response signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway cell-cell signaling nervous system development negative regulation of cell proliferation negative regulation of glutamate secretion response to purine-containing compound lipid catabolic process negative regulation of synaptic transmission, GABAergic positive regulation of nucleoside transport negative regulation of neurotrophin production positive regulation of dephosphorylation G-protein coupled purinergic nucleotide receptor signaling pathway vasodilation negative regulation of circadian sleep/wake cycle, sleep negative regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of apoptotic process positive regulation of potassium ion transport positive regulation of MAPK cascade negative regulation of blood pressure positive regulation of blood pressure negative regulation of hormone secretion negative regulation of inflammatory response cognition leukocyte migration detection of temperature stimulus involved in sensory perception of pain negative regulation of lipid catabolic process positive regulation of lipid catabolic process regulation of sensory perception of pain negative regulation of synaptic transmission, glutamatergic fatty acid homeostasis regulation of cardiac muscle contraction excitatory postsynaptic potential long term synaptic depression mucus secretion negative regulation of mucus secretion triglyceride homeostasis regulation of cardiac muscle cell contraction apoptotic signaling pathway regulation of presynaptic cytosolic calcium ion concentration negative regulation of long-term synaptic potentiation negative regulation of long term synaptic depression activation of MAPKK activity positive regulation of protein dephosphorylation negative regulation of renal sodium excretion regulation of vasodilation positive regulation of epidermal growth factor-activated receptor activity negative regulation of heart contraction negative regulation of vasodilation regulation of synaptic plasticity negative regulation of cardiac muscle contraction relaxation of vascular smooth muscle
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