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Invitrogen

ADORA2A Polyclonal Antibody

1 Published Figure
9 References
View all (21) ADORA2A antibodies

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ADORA2A Polyclonal Antibody

Product Details

PA1-042

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 4 publications 4 publications

Immunohistochemistry (IHC)

-
View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:10-1:100
-

Immunoprecipitation (IP)

Assay-dependent
-

Proximity Ligation Assay (PLA) (PLA)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Dog, Human, Mouse, Rat

Published species

Dog, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues E(373) S H G D M G L P D V E L L S H E L K(391) of canine A2aAR.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.69 mg/mL

Amount

69 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2257858

Product Specific Information

PA1-042 detects adenosine receptor A2a (A2aAR) in human, rat, mouse and canine tissues. This antibody does not detect other AR subtypes.

PA1-042 has been successfully used in Western blot, ICC/IF, immunohistochemistry and immunoprecipitation procedures. By Western blot, this antibody detects an ~45 kDa protein from canine striatum representing A2aAR. Immunohistochemical staining of A2aAR in human hippocampus with PA1-042 yields a pattern consistent with plasma membrane staining.

The PA1-042 immunogen is a synthetic peptide corresponding to residues E(373) S H G D M G L P D V E L L S H E L K(391) of canine A2aAR.

Target Information

ADORA2A is a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. This protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: A2a receptor; Adenosine A2a-receptor; Adenosine receptor A2a; adenosine receptor subtype A2a; ADORA2A; AR; hA2aR; unnamed protein product

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Gene Aliases: A2AAR; A2aR; AA2AR; ADENO; ADORA2; ADORA2A; Adora2l1; RDC8

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UniProt ID: (Human) P29274, (Dog) P11617, (Mouse) Q60613, (Rat) P30543

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Entrez Gene ID: (Human) 135, (Dog) 403960, (Mouse) 11540, (Rat) 25369

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Function(s)
G-protein coupled adenosine receptor activity G-protein coupled receptor activity protein binding calmodulin binding lipid binding enzyme binding type 5 metabotropic glutamate receptor binding identical protein binding macromolecular complex binding alpha-actinin binding signal transducer activity protein heterodimerization activity G-protein coupled receptor
Process(es)
synaptic transmission, dopaminergic adenosine receptor signaling pathway response to amphetamine regulation of transcription, DNA-templated phagocytosis apoptotic process inflammatory response cellular defense response signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway cell-cell signaling synaptic transmission, cholinergic central nervous system development blood coagulation sensory perception locomotory behavior blood circulation negative regulation of cell proliferation response to xenobiotic stimulus positive regulation of glutamate secretion positive regulation of acetylcholine secretion, neurotransmission regulation of norepinephrine secretion response to purine-containing compound response to caffeine positive regulation of synaptic transmission, GABAergic synaptic transmission, glutamatergic positive regulation of urine volume vasodilation eating behavior negative regulation of vascular permeability response to alkaloid negative regulation of neuron apoptotic process positive regulation of circadian sleep/wake cycle, sleep negative regulation of alpha-beta T cell activation astrocyte activation neuron projection morphogenesis positive regulation of protein secretion negative regulation of inflammatory response regulation of mitochondrial membrane potential membrane depolarization regulation of calcium ion transport positive regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential inhibitory postsynaptic potential prepulse inhibition positive regulation of ERK1 and ERK2 cascade apoptotic signaling pathway presynaptic modulation of chemical synaptic transmission positive regulation of long-term synaptic potentiation positive regulation of apoptotic signaling pathway negative regulation of protein kinase activity protein kinase C-activating G-protein coupled receptor signaling pathway positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway positive regulation of cAMP biosynthetic process positive regulation of renal sodium excretion negative regulation of locomotion negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of synaptic plasticity response to drug
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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