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Invitrogen

NEFL Polyclonal Antibody

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View all (74) NF-L antibodies

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Product Details

PA1-10000

Applications
Tested Dilution
Publications

Western Blot (WB)

1:20,000
-

Immunohistochemistry (IHC)

1:4,000
-

Immunocytochemistry (ICC/IF)

1:2,000
View 1 publication 1 publication
Product Specifications

Species Reactivity

Bovine, Human, Mouse, Pig, Rat

Published species

Human

Host/Isotype

Chicken / IgY

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant human NF-L protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1077181

Product Specific Information

PA1-10000 was made against a preparation of full length human recombinant NF-L protein. It binds NF-L from a variety of species including human, rat and mouse.

Target Information

Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-L is the light or low molecular weight microfilament subunit and runs on SDS-PAGE gels at approximately 70 kDa. Neurofilament are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-H is the heavy or high molecular weight microfilament subunit and runs on SDS-PAGE gels in the range 180-220 kDa, with some variation in different species.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 68 kDa neurofilament protein; FLJ53642; intermediate filament; light molecular weight neurofilament protein; Micro glutamic acid-rich protein; N-FL; NEF3; NEFL; neurofilament; neurofilament 3; Neurofilament light polypeptide; neurofilament protein L; neurofilament protein, light chain; neurofilament subunit NF-L; Neurofilament triplet L protein; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; neurofilament-l; neurofilament-light; NF-L; NF-M; NFM; NLC; OTTHUMP00000196614; protein phosphatase 1, regulatory subunit 110; unnamed protein product

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Gene Aliases: AI847934; CMT1F; CMT2E; CMTDIG; NEFL; NF-L; NF68; NFL; PPP1R110

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UniProt ID: (Bovine) P02548, (Human) P07196, (Mouse) P08551, (Rat) P19527

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Entrez Gene ID: (Bovine) 281348, (Human) 4747, (Pig) 100521224, (Mouse) 18039, (Rat) 83613

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Function(s)
structural constituent of cytoskeleton protein C-terminus binding protein binding, bridging identical protein binding structural constituent of postsynaptic intermediate filament cytoskeleton protein binding tubulin binding protein domain specific binding phospholipase binding macromolecular complex binding structural molecule activity protein heterodimerization activity
Process(es)
microtubule cytoskeleton organization anterograde axonal transport retrograde axonal transport peripheral nervous system axon regeneration axonal transport of mitochondrion regulation of axon diameter neurofilament bundle assembly locomotion negative regulation of neuron apoptotic process intermediate filament organization intermediate filament bundle assembly neuron projection morphogenesis positive regulation of axonogenesis neuromuscular process controlling balance neurofilament cytoskeleton organization synapse maturation postsynaptic intermediate filament cytoskeleton organization axonogenesis response to toxic substance spinal cord development hippocampus development cerebral cortex development response to peptide hormone intermediate filament polymerization or depolymerization protein polymerization response to corticosterone regulation of synapse maturation motor neuron apoptotic process postsynaptic modulation of chemical synaptic transmission response to sodium arsenite response to acrylamide negative regulation of motor neuron apoptotic process axon development response to organic substance response to organonitrogen compound
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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