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Invitrogen
Aromatase Polyclonal Antibody
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FIGURE: 1 / 6
Aromatase Antibody (PA1-16532) in ICC/IF
Immunocytochemistry analysis of Aromatase in U2OS cells. Samples were incubated with Aromatase polyclonal antibody (Product # PA1-16532) using a dilution of 2 µg/mL overnight at 4°C followed by anti-rabbit Dylight 488 (Green) at a dilution of 1:1,000 dilution for 60 minutes. Cells were fixed in 4% paraformaldehyde for 10 minutes and permeabilized in 0.05% Triton X-100 in PBS for 5 minutes. Nuclei were count... View More
Product Details
PA1-16532
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rabbit,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to a C-terminal portion of the human Aromatase protein (between residues 400-502).
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is expected to react with equine (91%), bovine and rabbit (90%), porcine (83%), ovine, goat and canine (81%) based on sequence homology.
Suggested positive control: antigen standard for CYP19A1 (transient overexpression lysate), human Fetal Temporal Lobe protein.
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Aromatase; aromatase precursor (EC 1.14.14.1); CYPXIX; cytochrome P-450-Arom; Cytochrome P-450AROM; Cytochrome P450 19A1; cytochrome P450 family 19 subfamily a; Cytochrome P450, 19, aromatase; cytochrome P450, family 19, subfamily A, polypeptide 1; cytochrome P450, subfamily 19; cytochrome P450, subfamily XIX (aromatization of androgens); Estrogen synthase; estrogen synthetase; flavoprotein-linked monooxygenase; MGC104309; microsomal monooxygenase; P-450AROM; unnamed protein product
Gene Aliases: Ar; ArKO; ARO; ARO1; Arom; Aromatase; CPV1; CYAR; CYP19; Cyp19a; CYP19A1; CYPXIX; Int-5; Int5; P-450AROM; p450arom
UniProt ID: (Rabbit) Q29605, (Human) P11511, (Mouse) P28649
Entrez Gene ID: (Rabbit) 100328545, (Human) 1588, (Mouse) 13075, (Rat) 25147
monooxygenase activity
iron ion binding
steroid hydroxylase activity
electron carrier activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
oxygen binding
heme binding
metal ion binding
aromatase activity
estrogen 2-hydroxylase activity
oxygenase
negative regulation of chronic inflammatory response
lipid metabolic process
steroid biosynthetic process
estrogen biosynthetic process
androgen catabolic process
syncytium formation
androgen metabolic process
female gonad development
negative regulation of macrophage chemotaxis
sterol metabolic process
female genitalia development
mammary gland development
response to estradiol
uterus development
prostate gland growth
testosterone biosynthetic process
positive regulation of estradiol secretion
C21-steroid hormone metabolic process
negative regulation of bone resorption
regulation of synapse structure or activity
oxidation-reduction process
luteinization
bile acid metabolic process
male gonad development
response to herbicide
response to metal ion
response to cesium ion
response to ionizing radiation
response to organic cyclic compound
biphenyl metabolic process
dibenzo-p-dioxin metabolic process
phthalate metabolic process
hippocampus development
hypothalamus development
melatonin metabolic process
adrenal gland development
granulocyte differentiation
response to testosterone
progesterone metabolic process
response to drug
response to morphine
response to estrogen
cellular response to fibroblast growth factor stimulus
bone development
cellular response to glucose stimulus
cellular response to gonadotropin stimulus
cellular response to follicle-stimulating hormone stimulus
cellular response to hydrostatic pressure
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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