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Invitrogen
HTR2B Polyclonal Antibody
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Product Details
PA1-20706
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 15 amino acid peptide from 2nd extracellular domain of human 5HT2B Receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
25 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-20706 detects 5-HT2B Receptor in human samples.
Target Information
HTR2B is a g-protein coupled receptor for 5-hydroxytryptamine (serotonin). It functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. HTR2B also plays a role in perception of pain, regulation of behavior. It is required to normal proliferation of embryonic cardiac myocytes and normal heart development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT 2B receptor; 5-HT-2B; 5-HT2b receptor; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B; 5HT2B Receptor; serotonin; Serotonin receptor 2B; unnamed protein product
Gene Aliases: 5-HT(2B); 5-HT-2B; 5-HT2B; HTR2B
UniProt ID: (Human) P41595
Entrez Gene ID: (Human) 3357
neural crest cell migration
positive regulation of cytokine production
positive regulation of endothelial cell proliferation
heart morphogenesis
cardiac muscle hypertrophy
cellular calcium ion homeostasis
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
phospholipase C-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
heart development
positive regulation of cell proliferation
response to xenobiotic stimulus
positive regulation of phosphatidylinositol biosynthetic process
neural crest cell differentiation
intestine smooth muscle contraction
calcium-mediated signaling
cGMP-mediated signaling
vasoconstriction
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
embryonic morphogenesis
regulation of behavior
release of sequestered calcium ion into cytosol
positive regulation of cell division
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
G protein-coupled serotonin receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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