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Invitrogen
HTR1B Polyclonal Antibody
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Product Details
PA1-41069
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mixture of synthetic peptides corresponding to amino acids 8-26 and 263-278 of rat 5-HT1BR.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: human, mouse, or rat brain.
Target Information
Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase. Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum. In situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT-1B; 5-HT-1D-beta; 5-HT1B receptor; 5-HT1B serotonin receptor; 5-HT<1B> receptor; 5-hydroxytryptamine (serotonin ) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; 5-hydroxytryptamine receptor 1B; 5HT1B Receptor; S12; serotonin (5-hydroxytryptamine (5HT)) receptor type 1B; Serotonin 1D beta receptor; Serotonin receptor 1B; unnamed protein product
Gene Aliases: 5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1DB; 5ht1b; HTR1B; HTR1D2; HTR1DB; S12
UniProt ID: (Human) P28222, (Mouse) P28334, (Rat) P28564
Entrez Gene ID: (Human) 3351, (Mouse) 15551, (Rat) 25075
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting serotonin receptor signaling pathway
phospholipase C-activating serotonin receptor signaling pathway
chemical synaptic transmission
negative regulation of serotonin secretion
vasoconstriction
bone remodeling
regulation of behavior
cellular response to alkaloid
cellular response to xenobiotic stimulus
positive regulation of vascular smooth muscle cell proliferation
G-protein coupled receptor internalization
protein kinase C-activating G-protein coupled receptor signaling pathway
serotonin receptor signaling pathway
behavior
feeding behavior
response to toxic substance
regulation of dopamine secretion
negative regulation of cAMP biosynthetic process
negative regulation of synaptic transmission, GABAergic
cellular response to drug
response to cocaine
response to drug
drinking behavior
response to ethanol
negative regulation of synaptic transmission, glutamatergic
cellular response to temperature stimulus
response to mineralocorticoid
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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