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Invitrogen
mGluR1/mGluR5 Polyclonal Antibody
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FIGURE: 1 / 1
mGluR1/mGluR5 Antibody (PA1-4663) in WB
Western blot of mGluR1/mGluR5 in HEK 293 cells (10 µg). Using a mGluR1/mGluR5 polyclonal antibody (Product # PA1-4663) it recognizes both mGluR5 (lane 1) and mGluR1a (lane 2), showing specific immunolabeling of a band at ~125 kDa corresponding to the monomer and a ~250 kDa band corresponding to the dimers for both receptors.
Product Details
PA1-4663
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the C-terminal region of rat GRM5 conjugated to KLH
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with human and mouse based on 100% sequence homology.
This antibody is specific for the ~125 kDa monomer and the ~250 kDa dimmers of mGluR5 and mGluR1 in Western blots of rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the peptide used to generate the antibody.
Target Information
may play a role in synaptic transmission; may interact with mGluR1, another group I metabotropic glutamate receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; G protein coupled receptor, family C, group 1, member E; G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member E; glutamate receptor; metabotropic glutamate receptor (mGluR5); Metabotropic glutamate receptor 1; Metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5; mGluR1; mGluR5; mGlurR1a
Gene Aliases: 4930455H15Rik; 6430542K11Rik; AI850523; ENSMUSG00000075319; Glu5R; Gm10828; Gprc1a; Gprc1e; Grm1; Grm5; Mglur1; Mglur5; mGluR5b; nmf373; rcw; wobl
UniProt ID: (Mouse) P97772, (Rat) P23385, (Rat) P31424, (Mouse) Q3UVX5
Entrez Gene ID: (Mouse) 14816, (Rat) 24414, (Rat) 24418, (Mouse) 108071
PLC activating G-protein coupled glutamate receptor activity
signal transducer activity
G-protein coupled receptor activity
protein binding
glutamate receptor activity
estrogen receptor binding
identical protein binding
calmodulin binding
PDZ domain binding
A2A adenosine receptor binding
G-protein coupled receptor
activation of MAPKK activity
activation of MAPK activity
signal transduction
G-protein coupled receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
locomotory behavior
sensory perception of pain
calcium-mediated signaling
dimeric G-protein coupled receptor signaling pathway
regulation of MAPK cascade
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
regulation of sensory perception of pain
regulation of synaptic transmission, glutamatergic
cellular response to electrical stimulus
chemical synaptic transmission
regulation of glutamate secretion
membrane depolarization
synaptic transmission, GABAergic
activation of MAPKKK activity
desensitization of G-protein coupled receptor protein signaling pathway
regulation of transcription, DNA-templated
protein phosphorylation
learning
negative regulation of locomotion
phosphatidylinositol-mediated signaling
regulation of long-term neuronal synaptic plasticity
positive regulation of long-term neuronal synaptic plasticity
cognition
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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