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Invitrogen
PER2 Polyclonal Antibody
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FIGURE: 1 / 6
PER2 Antibody (PA5-100107) in ICC/IF
Immunofluorescent analysis of PER2 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and PER2 polyclonal antibody (Product # PA5-100107) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-100107
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PER2(Accession O15055), corresponding to amino acid residues T463-R513.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PER2.
Target Information
PER2, also known as Period circadian protein homolog 2, is a mainly nuclear protein that shows nucleocytoplasmic shuttling which is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. PER2 belongs to the basic helix-loop-helix family of transcription factors and contains a PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. PER2 is a component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. This protein is thus essential for generating circadian rhythms and is a negative element in the circadian transcriptional loop which influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Expression of PER2 is fairly wide spread with strong expression in skeletal muscle and pancreas and slight expression in lung. Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Circadian clock protein PERIOD 2; hPER2; mPER2; per2 {ECO:0000312|RGD:61945}; period 2; period circadian clock 2; period circadian protein 2; Period circadian protein homolog 2; period homolog 2; rPER2; unnamed protein product
Gene Aliases: FASPS; FASPS1; KIAA0347; mKIAA0347; mPer2; PER2; rPER2
UniProt ID: (Human) O15055, (Mouse) O54943, (Rat) Q9Z301
Entrez Gene ID: (Human) 8864, (Mouse) 18627, (Rat) 63840
transcription regulatory region sequence-specific DNA binding
transcription corepressor binding
transcription coactivator activity
protein binding
transcription factor activity, transcription factor binding
core promoter binding
signal transducer activity
kinase binding
nuclear hormone receptor binding
pre-mRNA binding
histone deacetylase binding
ubiquitin binding
RNA polymerase binding
histone methyltransferase binding
transcription cofactor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
response to ischemia
neural retina development
glycogen biosynthetic process
gluconeogenesis
chromatin remodeling
fatty acid metabolic process
circadian rhythm
regulation of vasoconstriction
lactate biosynthetic process
negative regulation of protein ubiquitination
circadian regulation of gene expression
regulation of circadian rhythm
negative regulation of circadian rhythm
entrainment of circadian clock by photoperiod
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
rhythmic process
regulation of neurogenesis
regulation of insulin secretion
white fat cell differentiation
regulation of cell cycle
regulation of glutamate uptake involved in transmission of nerve impulse
negative regulation of fat cell proliferation
positive regulation of cold-induced thermogenesis
transcription, DNA-templated
signal transduction
negative regulation of DNA-templated transcription, termination
histone H3 deacetylation
circadian regulation of translation
negative regulation of transcription regulatory region DNA binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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