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Invitrogen
SFPQ Polyclonal Antibody
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FIGURE: 1 / 23
SFPQ Antibody (PA5-100111) in ICC/IF
Immunofluorescent analysis of SFPQ in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and SFPQ polyclonal antibody (Product # PA5-100111) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-100111
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SFPQ(Accession P23246), corresponding to amino acid residues Y597-G647.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SFPQ.
Target Information
SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 100 kDa DNA-pairing protein; DNA-binding p52/p100 complex, 100 kDa subunit; epididymis secretory sperm binding protein; hPOMp100; NonO/p54nrb homolog; polypyrimidine tract binding protein associated; polypyrimidine tract-binding protein-associated splicing factor; Polypyrimidine tract-binding protein-associated-splicing factor; protein phosphatase 1, regulatory subunit 140; PSF; PTB-associated splicing factor; PTB-associated-splicing factor; splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated); splicing factor proline/glutamine-rich; Splicing factor, proline- and glutamine-rich
Gene Aliases: 1110004P21Rik; 2810416M14Rik; 5730453G22Rik; 9030402K04Rik; AU021830; D4Ertd314e; Gm12940; OTTMUSG00000009329; POMP100; PPP1R140; PSF; REP1; SFPQ
UniProt ID: (Human) P23246, (Mouse) Q8VIJ6
Entrez Gene ID: (Human) 6421, (Mouse) 71514, (Rat) 252855
transcription regulatory region sequence-specific DNA binding
nucleic acid binding
DNA binding
chromatin binding
RNA binding
protein binding
protein homodimerization activity
histone deacetylase binding
nucleotide binding
core promoter binding
transcription regulatory region DNA binding
poly(A) RNA binding
RNA metabolism protein
negative regulation of transcription from RNA polymerase II promoter
alternative mRNA splicing, via spliceosome
double-strand break repair via homologous recombination
activation of innate immune response
immune system process
DNA repair
DNA recombination
chromatin remodeling
regulation of transcription, DNA-templated
mRNA processing
cellular response to DNA damage stimulus
RNA splicing
regulation of circadian rhythm
negative regulation of circadian rhythm
innate immune response
positive regulation of sister chromatid cohesion
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
chromosome organization
regulation of cell cycle
dendritic transport of messenger ribonucleoprotein complex
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
transcription, DNA-templated
histone H3 deacetylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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