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Invitrogen
CNOT6 Polyclonal Antibody
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Product Details
PA5-100444
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CNOT6(Accession Q9ULM6), corresponding to amino acid residues Y495-L545.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CNOT6.
Target Information
Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: carbon catabolite repression 4 protein; Carbon catabolite repressor protein 4 homolog; CCR4 carbon catabolite repression 4-like; CCR4-NOT transcription complex subunit 6; Cytoplasmic deadenylase; unnamed protein product
Gene Aliases: CCR4; CCR4a; CNOT6; KIAA1194; RGD1310783
UniProt ID: (Human) Q9ULM6, (Rat) Q6AXU9, (Mouse) Q8K3P5
Entrez Gene ID: (Human) 57472, (Rat) 287249, (Mouse) 104625
nuclear-transcribed mRNA poly(A) tail shortening
regulation of translation
positive regulation of cell proliferation
positive regulation of cytoplasmic mRNA processing body assembly
gene silencing by RNA
mRNA cleavage involved in gene silencing by miRNA
positive regulation of transcription, DNA-templated
nuclear-transcribed mRNA catabolic process, no-go decay
transcription, DNA-templated
regulation of transcription, DNA-templated
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
RNA phosphodiester bond hydrolysis, exonucleolytic
positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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