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Invitrogen

MICAL2 Polyclonal Antibody

View all (5) MICAL2 antibodies

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MICAL2 Polyclonal Antibody

Product Details

PA5-100613

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human MICAL2(Accession O94851), corresponding to amino acid residues K866-S916.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2850120

Product Specific Information

Antibody detects endogenous levels of total MICAL2.

Target Information

MICALs (Molecules Interacting with CasL) are atypical multidomain flavoenzymes with diverse cellular functions. There are three known isoforms, MICAL1, MICAL2 and MICAL3, as well as the MICAL-like proteins MICAL-L1 and MICAL-L2. MICAL2 has three conserved domains: an N-terminal flavin adenine dinucleotide (FAD) binding domain, a calponin homology (CH) domain and a Lin11, Isl-1 and Mec-3 (LIM) domain. It has been demonstrated that MICAL2 could regulate actin stress fibers and is required for normal actin organization. In addition, MICAL2-PV, a novel splicing variants of MICAL2, has been reported to be involved in cancer progression of prostate cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: [F-actin]-methionine sulfoxide oxidase MICAL2; [F-actin]-monooxygenase MICAL2; ebitein-1; ERK2-binding testicular protein 1; flavoprotein oxidoreductase MICAL2; MICAL C-terminal like; MICAL C-terminal-like protein; MICAL-2; Mical-cL; microtubule associated monoxygenase, calponin and LIM domain containing 2; mMical2; Molecule interacting with CasL protein 2; protein MICAL-2; Protein RSB-11-77; protein-methionine sulfoxide oxidase MICAL2; unnamed protein product

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Gene Aliases: 5330438E18Rik; 9530064J02; Ebitein1; KIAA0750; MICAL-2; mical-cL; MICAL2; MICAL2PV1; MICAL2PV2; MICALCL; mKIAA0750; RGD1311773

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UniProt ID: (Human) O94851, (Rat) D4A1F2, (Mouse) Q8BML1

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Entrez Gene ID: (Human) 9645, (Rat) 365352, (Mouse) 320878

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Function(s)
actin binding monooxygenase activity protein binding NAD(P)H oxidase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen metal ion binding mitogen-activated protein kinase binding FAD binding F-actin monooxygenase activity zinc ion binding NADPH:sulfur oxidoreductase activity 3-(3-hydroxyphenyl)propionate hydroxylase activity 4-chlorobenzaldehyde oxidase activity 3,5-xylenol methylhydroxylase activity phenylacetate hydroxylase activity 4-nitrophenol 4-monooxygenase activity dimethyl sulfide monooxygenase activity alpha-pinene monooxygenase [NADH] activity phenanthrene 9,10-monooxygenase activity 1-hydroxy-2-naphthoate hydroxylase activity toluene 4-monooxygenase activity xylene monooxygenase activity dibenzothiophene monooxygenase activity 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity chlorophenol 4-monooxygenase activity carbon disulfide oxygenase activity toluene 2-monooxygenase activity 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity phenanthrene 1,2-monooxygenase activity tetrahydrofuran hydroxylase activity styrene monooxygenase activity toluene-4-sulfonate monooxygenase activity toluene-sulfonate methyl-monooxygenase activity 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity 2-hydroxy-phenylacetate hydroxylase activity 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity phenanthrene 3,4-monooxygenase activity toluene 3-monooxygenase activity 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity limonene monooxygenase activity 2-methylnaphthalene hydroxylase activity 1-methylnaphthalene hydroxylase activity bisphenol A hydroxylase A activity salicylate 5-hydroxylase activity isobutylamine N-hydroxylase activity branched-chain dodecylbenzene sulfonate monooxygenase activity 3-HSA hydroxylase activity 4-hydroxypyridine-3-hydroxylase activity 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity 6-hydroxynicotinate 3-monooxygenase activity tocotrienol omega-hydroxylase activity thalianol hydroxylase activity
Process(es)
heart looping cytoskeleton organization heart development positive regulation of transcription via serum response element binding sulfur oxidation actin filament depolymerization oxidation-reduction process positive regulation of transcription from RNA polymerase II promoter metabolic process
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