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Invitrogen
VPS4B Polyclonal Antibody
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Product Details
PA5-100700
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human VPS4B(Accession O75351), corresponding to amino acid residues N78-R128.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total VPS4B.
Target Information
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell migration-inducing 1; Cell migration-inducing gene 1 protein; MIG1; Protein SKD1; Suppressor of K(+) transport growth defect 1; suppressor of K+ transport defect 1; unnamed protein product; vacuolar protein sorting 4B; Vacuolar protein sorting-associated protein 4B
Gene Aliases: 8030489C12Rik; MIG1; SKD1; SKD1B; VPS4-2; VPS42; VPS4B
UniProt ID: (Human) O75351, (Mouse) P46467
Entrez Gene ID: (Human) 9525, (Mouse) 20479, (Rat) 360834
nucleotide binding
protein binding
ATP binding
hydrolase activity
ATPase activity
identical protein binding
protein homodimerization activity
macromolecular complex binding
protein C-terminus binding
ATPase activity, coupled
molecular_function
microtubule-severing ATPase activity
non-motor microtubule binding protein
angiogenesis
plasma membrane repair
potassium ion transport
autophagy
nucleus organization
endosome organization
vacuole organization
vacuolar transport
lysosomal transport
mitotic metaphase plate congression
central nervous system development
regulation of G2/M transition of mitotic cell cycle
regulation of centrosome duplication
positive regulation of G2/M transition of mitotic cell cycle
protein transport
endosomal transport
macroautophagy
cholesterol transport
nuclear envelope reassembly
endosome to lysosome transport via multivesicular body sorting pathway
response to lipid
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
viral budding from plasma membrane
protein depolymerization
cell division
canonical Wnt signaling pathway
establishment of blood-brain barrier
late endosomal microautophagy
late endosome to lysosome transport via multivesicular body sorting pathway
midbody abscission
multivesicular body sorting pathway
membrane fission
ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
autophagosome maturation
regulation of mitotic spindle assembly
negative regulation of exosomal secretion
positive regulation of exosomal secretion
positive regulation of centriole elongation
ESCRT III complex disassembly
cell separation after cytokinesis
transport
cell cycle
viral release from host cell
positive regulation of viral process
regulation of viral process
negative regulation of cell death
positive regulation of viral release from host cell
positive regulation of viral life cycle
biological_process
cytoplasmic microtubule organization
intracellular cholesterol transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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