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Invitrogen
Cyclin T2 Polyclonal Antibody
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FIGURE: 1 / 2
Cyclin T2 Antibody (PA5-100709) in ICC/IF
Immunocytochemistry analysis of Cyclin T2 in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Cyclin T2 polyclonal antibody (Product # PA5-100709) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated g... View More
Product Details
PA5-100709
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CCNT2(Accession O60583), corresponding to amino acid residues S542-D592.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CCNT2.
Target Information
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclin T2a; cyclin T2b; Cyclin-T2; CycT2; SDS-stable vimentin-bound DNA fragment HEF42VIM22; subunit of positive elongation transcription factor b; unnamed protein product
Gene Aliases: 2900041I18Rik; C81304; CCNT2; CYCT2; CycT2a; CycT2b
UniProt ID: (Human) O60583, (Mouse) Q7TQK0
Entrez Gene ID: (Human) 905, (Mouse) 72949, (Rat) 304758
transcription coactivator binding
chromatin binding
protein binding
cyclin-dependent protein serine/threonine kinase regulator activity
protein kinase binding
cyclin-dependent protein serine/threonine kinase activator activity
RNA polymerase binding
7SK snRNA binding
molecular_function
kinase activator
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
skeletal muscle tissue development
early viral transcription
late viral transcription
positive regulation of DNA-templated transcription, elongation
positive regulation of transcription elongation from RNA polymerase II promoter
positive regulation by host of viral transcription
positive regulation of transcription from RNA polymerase II promoter
regulation of muscle cell differentiation
cell division
transcription, DNA-templated
regulation of transcription, DNA-templated
biological_process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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