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Invitrogen

HNF4A/HNF4G Polyclonal Antibody

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HNF4A/HNF4G Polyclonal Antibody

Product Details

PA5-100879

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human HNF4A(Accession P41235), corresponding to amino acid residues A287-L337.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2815829

Product Specific Information

Antibody detects endogenous levels of total HNF4 alpha /gamma.

Target Information

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha transcription factor 4; hepatic nuclear factor 4 alpha; hepatic nuclear factor 4, alpha; Hepatocyte nuclear factor 4-alpha; Hepatocyte nuclear factor 4-gamma; HNF-4-alpha; HNF-4-gamma; HNF4 alpha; HNF4A wild type; HNF4a7; HNF4a8; HNF4a9; HNF4alpha10; HNF4alpha10/11/12; HNF4alpha11; HNF4alpha12; HNF4G; Nuclear receptor 2A1; Nuclear receptor subfamily 2 group A member 1; Nuclear receptor subfamily 2 group A member 2; TCF-14; transcription factor; Transcription factor 14; Transcription factor HNF-4

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Gene Aliases: FRTS4; HNF-4; HNF4; HNF4A; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; HNF4G; MODY; MODY1; NR2A1; NR2A2; NR2A21; NR2A3; TCF; TCF-14; TCF14

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UniProt ID: (Human) P41235, (Human) Q14541, (Mouse) P49698, (Rat) P22449, (Mouse) Q9WUU6

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Entrez Gene ID: (Human) 3172, (Human) 3174, (Mouse) 15378, (Rat) 25735, (Mouse) 30942, (Rat) 365744

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding receptor binding fatty acid binding protein binding zinc ion binding protein homodimerization activity sequence-specific DNA binding metal ion binding RNA polymerase II sequence-specific DNA binding transcription factor binding sequence-specific double-stranded DNA binding fatty-acyl-CoA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding steroid hormone receptor activity transcription factor binding palmitoyl-CoA hydrolase activity transcription regulatory region DNA binding repressing transcription factor binding C4 zinc finger nuclear receptor
Process(es)
regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter lipid metabolic process xenobiotic metabolic process sex differentiation blood coagulation negative regulation of cell proliferation response to glucose gene expression regulation of gastrulation regulation of lipid metabolic process signal transduction involved in regulation of gene expression cell differentiation negative regulation of cell growth intracellular receptor signaling pathway glucose homeostasis cholesterol homeostasis regulation of circadian rhythm negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process regulation of insulin secretion lipid homeostasis phospholipid homeostasis regulation of growth hormone receptor signaling pathway triglyceride homeostasis regulation of ornithine metabolic process transcription, DNA-templated ornithine metabolic process acyl-CoA metabolic process establishment of tissue polarity regulation of microvillus assembly negative regulation of protein import into nucleus, translocation negative regulation of tyrosine phosphorylation of Stat5 protein steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity cell-cell junction organization positive regulation of gluconeogenesis positive regulation of fatty acid biosynthetic process negative regulation of mitotic cell cycle SMAD protein signal transduction negative regulation of activation of JAK2 kinase activity positive regulation of cholesterol homeostasis response to drug response to cAMP
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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