Search
Invitrogen
Contactin 2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 3
Contactin 2 Antibody (PA5-101541) in ICC/IF
Immunocytochemistry analysis of Contactin 2 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Contactin 2 polyclonal antibody (Product # PA5-101541) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugat... View More
Product Details
PA5-101541
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CNTN2(Accession Q02246), corresponding to amino acid residues S114-L164.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CNTN2.
Target Information
Contactin 2 (CNTN2, transiently-expressed axonal glycoprotein, AXT, TAX, TAX1, TAG-1, axonin 1) is a neuronal cell adhesion molecule (CAM) that influences the formation of axon connections in the developing nervous system. Contactin 2 is a member of the immunoglobulin superfamily (IgSF) and contains a glycosylphosphatidylinositol-anchor, six immunoglobulin (Ig)-like and four Fibronectin type III (FNIII)-like domains. Contactin 2 is expressed predominantly during neural development on the cell membrane of axons in nerve fiber tracts in order to guide commissural axons without promoting their growth. Contactin 2 binds with NgCAM in the plane of the same membrane (cis-binding). The Contactin 2 heterophilic (Contactin 2/NgCAM and Contactin 2/NrCAM) binding sites are localized to the first four Ig domains. The Contactin 2 homophilic (Contactin 2/Contactin 2) binding site is localized to the FNIII domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Axonal glycoprotein TAG-1; axonin; Axonin 1; Axonin-1; axonin-1 cell adhesion molecule; Axonin1; contactin 2 (axonal); contactin 2 (transiently expressed); Contactin-2; Contactin2; DKFZp781D102; MGC157722; TAX-1; Transient axonal glycoprotein 1; transiently-expressed axonal glycoprotein; unnamed protein product
Gene Aliases: AXT; CNTN2; D130012K04Rik; EPEO5; FAME5; TAG-1; TAG-564; TAG1; TAX; TAX1
UniProt ID: (Human) Q02246, (Mouse) Q61330, (Rat) P22063
Entrez Gene ID: (Human) 6900, (Mouse) 21367, (Rat) 25356
microtubule cytoskeleton organization
neuron migration
adenosine receptor signaling pathway
response to dietary excess
reduction of food intake in response to dietary excess
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
axon guidance
axonal fasciculation
learning
adult walking behavior
positive regulation of protein processing
protein processing
cerebral cortex GABAergic interneuron migration
central nervous system neuron differentiation
central nervous system myelination
regulation of cell morphogenesis
regulation of axon diameter
neuron projection development
receptor internalization
clustering of voltage-gated potassium channels
fat cell differentiation
negative regulation of neuron differentiation
regulation of neuronal synaptic plasticity
regulation of astrocyte differentiation
synapse organization
establishment of localization in cell
positive regulation of adenosine receptor signaling pathway
dendrite self-avoidance
protein localization to juxtaparanode region of axon
establishment of protein localization to juxtaparanode region of axon
presynaptic membrane organization
cell-matrix adhesion
axonogenesis
regulation of cell morphogenesis involved in differentiation
cellular protein localization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support