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Invitrogen
HOXA5 Polyclonal Antibody
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Product Details
PA5-101638
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human HOXA5(Accession P20719), corresponding to amino acid residues H63-D113.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total HOXA5.
Target Information
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. HOXA5 gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box 1C; homeo box A5; Homeobox protein Hox-1.3; Homeobox protein Hox-1C; Homeobox protein Hox-A5; homeobox protein HOXA5; Homeobox protein M2; hox-1.3; Hox-1C; HOXA5
Gene Aliases: Hox-1.3; HOX1; HOX1.3; HOX1C; Hoxa-5; HOXA5
UniProt ID: (Human) P20719, (Mouse) P09021
Entrez Gene ID: (Human) 3202, (Rat) 79241, (Mouse) 15402
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
molecular_function
sequence-specific DNA binding
homeodomain transcription factor
skeletal system development
morphogenesis of an epithelium
respiratory system process
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
pattern specification process
respiratory gaseous exchange
anterior/posterior pattern specification
positive regulation of gene expression
cell migration
negative regulation of angiogenesis
lung development
thyroid gland development
regulation of mammary gland epithelial cell proliferation
multicellular organism growth
positive regulation of apoptotic process
positive regulation of myeloid cell differentiation
negative regulation of erythrocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
embryonic skeletal system morphogenesis
embryonic skeletal system development
bronchiole development
trachea morphogenesis
epithelial tube branching involved in lung morphogenesis
lung goblet cell differentiation
lobar bronchus epithelium development
lung-associated mesenchyme development
trachea cartilage morphogenesis
cartilage morphogenesis
intestinal epithelial cell maturation
mesenchymal-epithelial cell signaling
mammary gland epithelial cell differentiation
mammary gland alveolus development
cell-cell signaling involved in mammary gland development
transcription, DNA-templated
multicellular organism development
positive regulation of receptor biosynthetic process
transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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