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Invitrogen
EDG4 Polyclonal Antibody
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FIGURE: 1 / 2
EDG4 Antibody (PA5-102074) in IHC (P)
Immunohistochemistry analysis of EDG4 in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with EDG4 polyclonal antibody (Product # PA5-102074) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-102074
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LPAR2(Accession Q9HBW0), corresponding to amino acid residues Y295-P345.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total EDG4.
Target Information
Edg4 is a Lysophospholipid/Lysosphingolipid Receptor activated by phosphatidic acid (PA) and lysophosphatidic acid (LPA). It enhances the transcription of serum response element (SRE) reporter genes. In CD4(+) T cells, Edg4 may be involved in the control of interleukin-2 secretion. Edg4 expression has been documented in leukocytes, pancreas, spleen, thymus, prostate, and testis. Edg4 expression has also been seen in many cancer cell lines, including those of brain, blood, breast, ovary, cervix, colon, skin, and thyroid. ESTs have been isolated from B-cell/lung/testis, blood, brain, embryo, heart/melanocyte/uterus, liver, placenta, prostate, and skin libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EDG4; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4; G protein-coupled receptor; LPA receptor 2; LPA receptor EDG4; LPA-2; LPA2 Receptor; Lysophosphatidic acid receptor 2; Lysophosphatidic acid receptor Edg-4; lysophosphatidic acid receptor EDG4; seven transmembrane G protein-coupled receptor; short form; similar to LPA receptor; unnamed protein product
Gene Aliases: EDG-4; EDG4; IPA2; LPA-2; LPA2; LPAR2
UniProt ID: (Human) Q9HBW0, (Mouse) Q9JL06
Entrez Gene ID: (Human) 9170, (Mouse) 53978
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of Rho protein signal transduction
positive regulation of MAPK cascade
activation of MAPK activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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