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Invitrogen
Cathepsin H Polyclonal Antibody
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FIGURE: 1 / 5
Cathepsin H Antibody (PA5-103115) in IHC (P)
Immunohistochemistry analysis of Cathepsin H in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Cathepsin H polyclonal antibody (Product # PA5-103115) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-103115
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CTSH(Accession P09668), corresponding to amino acid residues S83-K133.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Cathepsin H.
Target Information
The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cathepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E. Cathepsin G is in the serine protease class. Most cathepsins are lysosomal and each is involved in various cellular events such as peptide biosynthesis and protein degradation. The propeptide region of cathepsin H is highly homologous to other cathepsins. This region is thought to play a role in the processing of cysteine proteases. Cathepsin H is thought to be involved in several pathological conditions, including neuro degenerative disorders and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aleurain; Cat H; CATH; Cathepsin B3; Cathepsin BA; CTSH; N-benzoylarginine-beta-naphthylamide hydrolase; Pro-cathepsin H; protease; unnamed protein product
Gene Aliases: ACC-4; ACC-5; ACC4; ACC5; AL022844; CPSB; CTSH
UniProt ID: (Human) P09668, (Mouse) P49935
Entrez Gene ID: (Human) 1512, (Mouse) 13036
endopeptidase activity
aminopeptidase activity
cysteine-type endopeptidase activity
serine-type endopeptidase activity
protein binding
peptidase activity
cysteine-type peptidase activity
cysteine-type endopeptidase activator activity involved in apoptotic process
peptidase activator activity involved in apoptotic process
hydrolase activity
HLA-A specific activating MHC class I receptor activity
kininogen binding
identical protein binding
macromolecular complex binding
thyroid hormone binding
protein complex binding
protein self-association
cysteine protease
metanephros development
T cell mediated cytotoxicity
adaptive immune response
immune response-regulating signaling pathway
proteolysis
apoptotic process
immune response
spermatogenesis
positive regulation of gene expression
positive regulation of epithelial cell migration
neuropeptide catabolic process
bradykinin catabolic process
antigen processing and presentation
positive regulation of cell migration
zymogen activation
protein destabilization
response to retinoic acid
membrane protein proteolysis
surfactant homeostasis
proteolysis involved in cellular protein catabolic process
dichotomous subdivision of terminal units involved in lung branching
ERK1 and ERK2 cascade
cellular response to thyroid hormone stimulus
lysosomal protein catabolic process
response to odorant
positive regulation of apoptotic signaling pathway
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cell proliferation
positive regulation of peptidase activity
negative regulation of apoptotic process
positive regulation of angiogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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