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Invitrogen
PIKFYVE Polyclonal Antibody
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FIGURE: 1 / 2
PIKFYVE Antibody (PA5-103242) in IHC (P)
Immunohistochemistry analysis of PIKFYVE in mouse heart tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PIKFYVE polyclonal antibody (Product # PA5-103242) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-103242
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PIKFYVE(Accession Q9Y2I7), corresponding to amino acid residues T283-N333.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PIP5K.
Target Information
PIKFYVE belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. The content of phosphatidylinositol 3,5-bisphosphateP2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. PIKFYVE is the PtdIns(3,5)P2-producing component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PIKFYVE activator VAC14 and the PtdIns(3,5)P2 phosphatase FIG4. In addition to its phosphoinositide 5-kinase activity, PIKFYVE also has protein kinase activity. For a review, see Shisheva.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1-phosphatidylinositol 3-phosphate 5-kinase; 1-phosphatidylinositol-3-phosphate 5-kinase; epididymis luminal protein 37; FYVE finger-containing phosphoinositide kinase; p235; Phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphatidylinositol-4-phosphate 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; PIKfyve; PIPkin-III; PtdIns(4)P-5-kinase; Serine-protein kinase PIKFYVE; type III PIP kinase; unnamed protein product; zinc finger, FYVE domain containing 29
Gene Aliases: 5230400C17Rik; CFD; FAB1; HEL37; KIAA0981; p235; PIKFYVE; PIP5K; PIP5K3; Pipk5k3; PipkIII; ZFYVE29
UniProt ID: (Human) Q9Y2I7, (Mouse) Q9Z1T6
Entrez Gene ID: (Human) 200576, (Mouse) 18711
nucleotide binding
1-phosphatidylinositol-3-phosphate 5-kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
zinc ion binding
kinase activity
1-phosphatidylinositol-4-phosphate 5-kinase activity
transferase activity
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
metal ion binding
phosphatidylinositol kinase activity
1-phosphatidylinositol-5-kinase activity
protein serine kinase activity
phosphatidylinositol phosphate kinase activity
kinase
transferase
metabolite interconversion enzyme
protein targeting to membrane
lipid metabolic process
phosphatidylinositol biosynthetic process
receptor-mediated endocytosis
protein localization
receptor-mediated endocytosis of virus by host cell
antigen processing and presentation of exogenous peptide antigen via MHC class II
neutrophil chemotaxis
melanosome organization
protein localization to nucleus
intracellular signal transduction
phosphatidylinositol-3-phosphate biosynthetic process
peptidyl-serine autophosphorylation
retrograde transport, endosome to Golgi
phosphatidylinositol metabolic process
phagosome maturation
phagosome-lysosome fusion
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process
regulation of reactive oxygen species biosynthetic process
phosphatidylinositol 5-phosphate metabolic process
regulation of autophagosome assembly
phosphorylation
myelin assembly
phosphatidylinositol phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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