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Invitrogen
Kir4.1 (KCNJ10) Polyclonal Antibody
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FIGURE: 1 / 4
Kir4.1 (KCNJ10) Antibody (PA5-103644) in IHC (P)
Immunohistochemistry analysis of Kir4.1 (KCNJ10) in rat colorectal tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Kir4.1 (KCNJ10) polyclonal antibody (Product # PA5-103644) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-103644
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KCNJ10(Accession P78508), corresponding to amino acid residues R199-L249.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total KCNJ10.
Target Information
The KIR (for inwardly rectifying potassium channel) family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. KIR4.1, also known as Kir1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. KIR4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human KIR4.1 maps to chromosome 1. KIR4.2, also known as Kir1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human KIR4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and KIR4.2 may play a role in the pathogenesis of Downs syndrome. KIR5.1 forms functional channels only by coexpression with either KIR4.1 or KIR4.2 in the kidney and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent inwardly rectifying potassium channel Kir4.1; ATP-sensitive inward rectifier potassium channel 10; ATP-sensitive inward rectifier potassium channel KAB-2; BIR10; BIRK1; BIRK10; Brain-specific inwardly rectifying K(+) channel 1; glial ATP-dependent inwardly rectifying potassium channel KIR4.1; Inward rectifier K(+) channel Kir1.2; Inward rectifier K(+) channel Kir4.1; inward rectifier K+ channel KIR1.2; KCNJ13 PEN; kir4.1; Potassium channel, inwardly rectifying subfamily J member 10; potassium inwardly-rectifying channel, subfamily J, member 10; potassium voltage-gated channel subfamily J member 10; unnamed protein product
Gene Aliases: BIR10; BIRK-1; BIRK-10; Kab-2; KCNJ10; KCNJ13-PEN; KIR1.2; KIR4.1; SESAME
UniProt ID: (Human) P78508, (Rat) P49655, (Mouse) Q9JM63
Entrez Gene ID: (Human) 3766, (Rat) 29718, (Mouse) 16513
ion transport
potassium ion transport
visual perception
adult walking behavior
oligodendrocyte development
central nervous system myelination
metal ion transport
ion transmembrane transport
regulation of ion transmembrane transport
cellular response to potassium ion
regulation of membrane potential
regulation of long-term neuronal synaptic plasticity
establishment of localization in cell
glutamate reuptake
potassium ion homeostasis
regulation of resting membrane potential
potassium ion transmembrane transport
non-motile cilium assembly
potassium ion import across plasma membrane
inflammatory response
response to blue light
potassium ion import
optic nerve development
protein homotetramerization
response to glucocorticoid
response to mineralocorticoid
regulation of sensory perception of pain
L-glutamate import
membrane hyperpolarization
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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