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Invitrogen
INPP5J Polyclonal Antibody
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FIGURE: 1 / 5
INPP5J Antibody (PA5-104005) in ICC/IF
Immunocytochemistry analysis of INPP5J in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with INPP5J polyclonal antibody (Product # PA5-104005) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-104005
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human INPP5J(Accession Q15735), corresponding to amino acid residues G946-H996.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total INPP5J.
Target Information
Inositol and phosphatidylinositol phosphates are important for numerous cellular processes, including neuronal survival and signal transductions from growth factors, neurotransmitters and G protein coupled receptors. INPP5J (inositol polyphosphate-5-phosphatase J), also known as phosphatidylinositol 4,5-bisphosphate 5-phosphatase A, PIPP (proline-rich inositol polyphosphate 5-phosphatase), PIB5PA or INPP5, is a 1,006 amino acid cytoplasmic protein that assists in the conversion of inositol 1,4-bisphosphate from inositol 1,4,5-trisphosphate. Expressed in lung, stomach, kidney, brain, small intestine and heart, INPP5J localizes to membrane ruffles, where it may also participate in modulating inositol and phosphatidylinositol polyphosphate-binding proteins. Encoded by a gene located on human chromosome 22, INPP5J undergoes alternative splicing to produce three isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Inositol polyphosphate 5-phosphatase J; phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A; phosphatidylinositol (4,5)bisphosphate 5-phosphatase homolog; Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase; Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; Proline-rich inositol polyphosphate 5-phosphatase; unnamed protein product
Gene Aliases: Inpp; INPP5; INPP5J; PIB5PA; PIPP
UniProt ID: (Human) Q15735, (Rat) Q9JMC1
Entrez Gene ID: (Human) 27124, (Rat) 171088
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
inositol-polyphosphate 5-phosphatase activity
protein binding
hydrolase activity
phosphatase activity
SH3 domain binding
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
inositol trisphosphate phosphatase activity
inositol-1,4,5-trisphosphate 5-phosphatase activity
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
phosphatase
phospholipid metabolic process
phosphatidylinositol biosynthetic process
negative regulation of neuron projection development
negative regulation of microtubule polymerization
inositol phosphate metabolic process
glycerolipid metabolic process
phosphatidylinositol dephosphorylation
dephosphorylation
negative regulation of peptidyl-serine phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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