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Invitrogen
SCN11A Polyclonal Antibody
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FIGURE: 1 / 2
SCN11A Antibody (PA5-104156) in ICC/IF
Immunocytochemistry analysis of SCN11A in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with SCN11A polyclonal antibody (Product # PA5-104156) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-104156
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SCN11A(Accession Q9UI33), corresponding to amino acid residues E473-L523.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SCN11A.
Target Information
Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddels syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hNaN; NaN alpha subunit; Peripheral nerve sodium channel 5; PN5; Sensory neuron sodium channel 2; Sodium channel protein type 11 subunit alpha; Sodium channel protein type XI subunit alpha; sodium channel, voltage-gated, type XI, alpha; sodium channel, voltage-gated, type XI, alpha polypeptide; sodium channel, voltage-gated, type XI, alpha subunit; sodium channel, voltage-gated, type XII, alpha polypeptide; Voltage-gated sodium channel subunit alpha Nav1.9
Gene Aliases: FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN11A; SCN12A; SNS-2; SNS2
UniProt ID: (Human) Q9UI33
Entrez Gene ID: (Human) 11280
action potential
thigmotaxis
acute inflammatory response
chronic inflammatory response
ion transport
sodium ion transport
inflammatory response
G-protein coupled receptor signaling pathway
axonogenesis
circadian rhythm
chemosensory behavior
response to heat
response to cold
response to xenobiotic stimulus
response to toxic substance
response to high light intensity
response to auditory stimulus
transmission of nerve impulse
neuronal action potential
sensory perception of pain
ion transmembrane transport
response to prostaglandin E
sodium ion transmembrane transport
thermosensory behavior
regulation of membrane potential
mast cell degranulation
response to pain
behavioral response to pain
cell motility
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception
establishment of localization in cell
transmembrane transport
reflex
micturition
skeletal muscle organ development
artery development
behavioral response to acetic acid induced pain
behavioral response to formalin induced pain
cellular response to cold
calcium ion transmembrane transport
response to nitric oxide
cardiac muscle cell action potential involved in contraction
membrane depolarization during action potential
action potential initiation
cAMP/PKA signal transduction
sensory perception of itch
calcitonin gene-related peptide receptor signaling pathway
small intestine smooth muscle contraction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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