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Invitrogen

HDAC7 Polyclonal Antibody

View all (24) HDAC7 antibodies

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HDAC7 Polyclonal Antibody

Product Details

PA5-104214

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human HDAC7(Accession Q8WUI4), corresponding to amino acid residues V912-L952.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2853541

Product Specific Information

Antibody detects endogenous levels of total HDAC7.

Target Information

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HD7; HD7a; hdac-7; Histone deacetylase 7; Histone deacetylase 7A; Protein deacetylase HDAC7; unnamed protein product

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Gene Aliases: 5830434K02Rik; HD7; HD7A; HDAC7; HDAC7A; mFLJ00062

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UniProt ID: (Human) Q8WUI4, (Mouse) Q8C2B3

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Entrez Gene ID: (Human) 51564, (Mouse) 56233

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Function(s)
chromatin binding transcription corepressor activity histone deacetylase activity protein kinase C binding protein binding hydrolase activity SUMO transferase activity protein kinase binding protein deacetylase activity metal ion binding 14-3-3 protein binding DNA-binding transcription factor binding histone deacetylase activity, hydrolytic mechanism transcription factor binding histone deacetylase activity (H3-K14 specific) NAD-dependent histone deacetylase activity (H3-K14 specific) histone deacetylase activity (H3-K9 specific) activating transcription factor binding histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) repressing transcription factor binding NAD-dependent histone deacetylase activity (H3-K18 specific) histone modifying enzyme
Process(es)
negative regulation of transcription from RNA polymerase II promoter vasculogenesis chromatin organization protein deacetylation cell-cell junction assembly negative regulation of macromolecule biosynthetic process protein sumoylation negative regulation of interleukin-2 production regulation of gene expression, epigenetic negative regulation of osteoblast differentiation negative regulation of transcription, DNA-templated regulation of mRNA processing positive regulation of cell migration involved in sprouting angiogenesis membraneless organelle assembly negative regulation of NIK/NF-kappaB signaling transcription, DNA-templated regulation of transcription, DNA-templated inflammatory response nervous system development chromatin modification histone deacetylation B cell differentiation B cell activation negative regulation of striated muscle tissue development negative regulation of neuron death
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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