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Invitrogen
Collagen IV Polyclonal Antibody
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Product Details
PA5-104508
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human COL4A1(Accession P02462), corresponding to amino acid residues A27-Q77.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Collagen IV.
Target Information
Collagen IV is a type of collagen protein that is a major component of the basement membrane in various tissues, including the kidneys, lungs, and skin. It forms a network-like structure that provides support and stability to the surrounding tissue. Collagen IV is composed of three alpha chains, which are encoded by the COL4A1, COL4A2, and COL4A3 genes. Mutations in these genes can lead to various genetic disorders, such as Alport syndrome and Goodpasture syndrome, which affect the kidneys and lungs, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: a matrix-derived inhibitor of angiogenesis and tumor growth; a3(IV)NC1; alpha 1 type IV collagen; alpha-2 collagen type IV; alpha1(IV) collagen; arresten; canstatin; COL4A1 NC1 domain; COL4A2 NC1 domain; col4a3; COL4A3 NC1 domain; col4a4; Collagen 4; Collagen alpha-1(IV) chain; collagen alpha-2 type IV; Collagen alpha-2(IV) chain; Collagen alpha-3(IV) chain; Collagen alpha-4(IV) chain; Collagen alpha-5(IV) chain; Collagen alpha-6(IV) chain; collagen IV, alpha-1 polypeptide; collagen IV, alpha-3 polypeptide; Collagen IV, alpha-4 polypeptide; collagen IV, alpha-5 polypeptide; collagen IV, alpha-6 polypeptide; collagen of basement membrane, alpha-1 chain; collagen of basement membrane, alpha-4 chain; collagen of basement membrane, alpha-5 chain; collagen of basement membrane, alpha-6; collagen type IV alpha 5 chain; collagen type IV alpha3 chain; collagen type IV alpha5 chain; collagen, type IV, alpha 3 (Goodpasture antigen); collagen, type IV, alpha 4; collagen, type IV, alpha 5; collagen, type IV, alpha 6; contains COL4A1 NC1 domain; dA149D17.3; dA24A23.1; Del(8)Bru44H; dJ889N15.4 (Collagen Alpha 6(IV)); Goodpasture antigen; matrix-derived inhibitor of angiogenesis and tumor growth; non-collagenous 1 domain from alpha 1 chain of type IV collagen; pro-alpha-1(IV); procollagen alpha-1 type IV; procollagen type IV alpha 5; procollagen type IV alpha 6; procollagen, type IV, alpha 1; procollagen, type IV, alpha 2; procollagen, type IV, alpha 3; procollagen, type IV, alpha 4; procollagen, type IV, alpha 5; procollagen, type IV, alpha 6; retinal anterior wiring; soluble Col4A1 protein; structural non-collagenous NC1 domain; a6[IV]NC1; tumstatin; Type IV Collagen; unnamed protein product
Gene Aliases: [a]3(IV); [a]4(IV); alpha3(IV); ASLN; ATS; ATS1; ATS2; ATS3; ATS3A; ATS3B; BB116301; BFH; BFH1; BFH2; Bru; BSVD; BSVD1; BSVD2; CA44; CA54; Col4a-1; Col4a-2; COL4A1; COL4A1s; COL4A2; COL4A3; COL4A4; COL4A5; COL4A6; CXDELq22.3; Del(8)44H; DELXq22.3; DFNX6; E130010M05Rik; ICH; PADMAL; POREN2; RATOR; Raw; RGD1565499; Svc
extracellular matrix structural constituent
protein binding
extracellular matrix structural constituent conferring tensile strength
platelet-derived growth factor binding
binding, bridging
integrin binding
structural molecule activity
metalloendopeptidase inhibitor activity
molecular_function
extracellular matrix structural protein
angiogenesis
patterning of blood vessels
brain development
neuromuscular junction development
epithelial cell differentiation
collagen-activated tyrosine kinase receptor signaling pathway
blood vessel morphogenesis
retinal blood vessel morphogenesis
renal tubule morphogenesis
cellular response to amino acid stimulus
basement membrane organization
transcription, DNA-templated
response to activity
negative regulation of angiogenesis
extracellular matrix organization
endodermal cell differentiation
cellular response to transforming growth factor beta stimulus
cell adhesion
cell surface receptor signaling pathway
sensory perception of sound
negative regulation of cell proliferation
glomerular basement membrane development
endothelial cell apoptotic process
negative regulation of vascular endothelial cell proliferation
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell proliferation
response to glucose
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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