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Invitrogen

Phospho-PKD2 (Ser812) Polyclonal Antibody

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Phospho-PKD2 (Ser812) Polyclonal Antibody

Product Details

PA5-104567

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PKD2(Accession Q13563), corresponding to amino acid residues around phosphorylated Ser812.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816042

Product Specific Information

Antibody detects endogenous levels of PKD2 only when phosphorylated at Ser812.

Target Information

This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A MGC138466; autosomal dominant polycystic kidney disease type II; Autosomal dominant polycystic kidney disease type II protein; MGC138468; PC2; PKD2; polycystic kidney disease 2 (autosomal dominant); polycystic kidney disease 2 homolog; Polycystic kidney disease 2 protein; Polycystic kidney disease 2 protein homolog; Polycystin 2; Polycystin-2; Polycystwin; R48321; Transient receptor potential cation channel subfamily P member 2; TRPP1; unnamed protein product

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Gene Aliases: APKD2; C030034P18Rik; Pc-2; PC2; PKD2; PKD4; RGD1559992; TRPP1; TRPP2

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UniProt ID: (Human) Q13563, (Mouse) O35245

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Entrez Gene ID: (Human) 5311, (Rat) 498328, (Mouse) 18764

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Function(s)
receptor binding voltage-gated ion channel activity voltage-gated calcium channel activity voltage-gated sodium channel activity voltage-gated potassium channel activity cation channel activity calcium channel activity potassium channel activity sodium channel activity calcium ion binding protein binding cytoskeletal protein binding channel activity outward rectifier potassium channel activity voltage-gated cation channel activity identical protein binding protein homodimerization activity actinin binding HLH domain binding ion channel binding metal ion binding calcium-induced calcium release activity ATPase binding phosphoprotein binding muscle alpha-actinin binding transcription regulator inhibitor activity alpha-actinin binding ion channel
Process(es)
branching involved in ureteric bud morphogenesis kidney development liver development embryonic placenta development heart looping detection of nodal flow ion transport potassium ion transport sodium ion transport calcium ion transport cellular calcium ion homeostasis cell surface receptor signaling pathway JAK-STAT cascade determination of left/right symmetry heart development negative regulation of cell proliferation positive regulation of gene expression Wnt signaling pathway calcium-mediated signaling spinal cord development neural tube development ion transmembrane transport cellular response to reactive oxygen species metanephric part of ureteric bud development sodium ion transmembrane transport aorta development regulation of cell proliferation chordate embryonic development cilium organization positive regulation of nitric oxide biosynthetic process positive regulation of transcription from RNA polymerase II promoter embryonic organ development detection of mechanical stimulus release of sequestered calcium ion into cytosol protein tetramerization protein homotetramerization protein heterotetramerization centrosome duplication establishment of localization in cell regulation of cell cycle placenta blood vessel development renal tubule morphogenesis renal artery morphogenesis calcium ion transmembrane transport cellular response to calcium ion cellular response to cAMP cellular response to hydrostatic pressure cellular response to osmotic stress cellular response to fluid shear stress potassium ion transmembrane transport determination of liver left/right asymmetry metanephric mesenchyme development mesonephric tubule development mesonephric duct development metanephric smooth muscle tissue development metanephric cortex development metanephric ascending thin limb development metanephric cortical collecting duct development metanephric distal tubule development metanephric S-shaped body morphogenesis regulation of calcium ion import inorganic cation transmembrane transport positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway negative regulation of G1/S transition of mitotic cell cycle cell cycle arrest positive regulation of cytosolic calcium ion concentration regulation of cAMP metabolic process positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle cytoplasmic sequestering of transcription factor transmembrane transport negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of cell cycle arrest renal system development transport
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