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Invitrogen

Phospho-PLCG2 (Tyr1217) Polyclonal Antibody

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Phospho-PLCG2 (Tyr1217) Polyclonal Antibody

Product Details

PA5-104632

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PLCG2(Accession P16885), corresponding to amino acid residues around phosphorylated Tyr1217.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816107

Product Specific Information

Antibody detects endogenous levels of PLCG2 only when phosphorylated at Tyr1217.

Target Information

Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC beta1, PLC beta2, PLC beta3, PLC beta4, PLC gamma1, PLC gamma2, PLC delta1, PLC delta2 and PLCe. PLC delta exists as four different isoforms. PLC delta1, a calcium signal amplifier, is activated by an atypical GTP-binding protein. In addition, PLC delta1 is an effector for GTP-binding protein transglutaminase II-mediated oxytocin receptor and alpha1B-adrenoreceptor signaling. Mouse PLC delta1 is highly expressed in brain, heart, lung and testis. PLC delta is abnormally accumulated in autopsied brains with Alzheimer's disease (AD), suggesting that it may play a role in the pathology of AD. PLC delta2 is markedly expressed in type II intestinal metaplasia and in the adenocarcinoma. When PLC delta2 is expressed in type I intestinal metaplasia, the metaplasia is generally considered benignant, yet evolves toward neoplastic transformation. Thus, PLC delta2 expression may be a possible marker of gastric malignant transformation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-gamma-2; phospholipase C; phospholipase C, gamma 2 (phosphatidylinositol-specific); Phospholipase C-gamma-2; Phospholipase C-IV; PLC gamma 2; PLC gamma-2; PLC gamma2; PLC- gamma2; PLC-gamma; PLC-gamma-2; PLC-IV; unnamed protein product

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Gene Aliases: APLAID; FCAS3; PLC-gamma-2; PLC-IV; Plcg-2; PLCG2; PLCgamma2

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UniProt ID: (Human) P16885, (Rat) P24135, (Mouse) Q8CIH5

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Entrez Gene ID: (Human) 5336, (Rat) 29337, (Mouse) 234779

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Function(s)
phosphotyrosine binding phosphatidylinositol phospholipase C activity phospholipase C activity protein binding phosphoric diester hydrolase activity hydrolase activity protein kinase binding scaffold protein binding phosphorylation-dependent protein binding protein tyrosine kinase binding signal transducer activity phospholipase
Process(es)
cell activation response to yeast positive regulation of receptor internalization stimulatory C-type lectin receptor signaling pathway toll-like receptor signaling pathway macrophage activation involved in immune response follicular B cell differentiation positive regulation of dendritic cell cytokine production lipid metabolic process phosphatidylinositol biosynthetic process signal transduction phospholipid catabolic process regulation of gene expression positive regulation of gene expression positive regulation of epithelial cell migration programmed cell death lipid catabolic process Wnt signaling pathway regulation of lipid metabolic process calcium-mediated signaling platelet activation B cell differentiation lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production response to lipopolysaccharide positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-2 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production inositol trisphosphate biosynthetic process intracellular signal transduction Fc-epsilon receptor signaling pathway B cell activation negative regulation of programmed cell death regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade phosphatidylinositol metabolic process phosphatidylinositol-mediated signaling response to axon injury positive regulation of calcium-mediated signaling antigen receptor-mediated signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway release of sequestered calcium ion into cytosol regulation of sequestering of calcium ion positive regulation of phagocytosis, engulfment positive regulation of macrophage cytokine production antifungal innate immune response regulation of calcineurin-NFAT signaling cascade cellular response to calcium ion cellular response to lipid positive regulation of neuroinflammatory response positive regulation of NLRP3 inflammasome complex assembly positive regulation of intracellular signal transduction positive regulation of cell cycle G1/S phase transition positive regulation of reactive oxygen species biosynthetic process cellular response to lectin positive regulation of cytosolic calcium ion concentration response to magnesium ion activation of store-operated calcium channel activity response to ATP
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