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Invitrogen
Phospho-p73 (Tyr99) Polyclonal Antibody
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FIGURE: 1 / 10
Phospho-p73 (Tyr99) Antibody (PA5-104698) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-p73 (Tyr99) in human appendiceal tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-p73 (Tyr99) polyclonal antibody (Product # PA5-104698) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-104698
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TP73(Accession O15350), corresponding to amino acid residues around phosphorylated Tyr99.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of p73 only when phosphorylated at Tyrosine 99.
Target Information
P73 (TP73) participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTTHUMP00000003479; OTTHUMP00000003480; p53-like transcription factor; p53-related protein; P73; RP23-254N4.10; transformation related protein 73; Tumor protein p73; unnamed protein product
Gene Aliases: CILD47; deltaNp73; P73; TAp73; TP73; Trp73
UniProt ID: (Human) O15350, (Mouse) Q9JJP2
Entrez Gene ID: (Human) 7161, (Rat) 362675, (Mouse) 22062
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription corepressor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
p53 binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein kinase binding
identical protein binding
sequence-specific DNA binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
MDM2/MDM4 family protein binding
DNA-binding transcription factor binding
promoter-specific chromatin binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
transcription factor binding
transcription regulatory region DNA binding
P53-like transcription factor
kidney development
release of cytochrome c from mitochondria
mismatch repair
regulation of transcription, DNA-templated
apoptotic process
inflammatory response
cellular response to DNA damage stimulus
regulation of mitotic cell cycle
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
response to xenobiotic stimulus
post-embryonic development
regulation of gene expression
hippocampus development
forebrain development
cerebrospinal fluid secretion
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of MAPK cascade
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
positive regulation of cell differentiation
negative regulation of neuron differentiation
positive regulation of cell size
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
digestive tract morphogenesis
neuron development
positive regulation of oligodendrocyte differentiation
protein tetramerization
regulation of cell cycle
negative regulation of cardiac muscle cell proliferation
positive regulation of lung ciliated cell differentiation
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of apoptotic signaling pathway
negative regulation of transcription from RNA polymerase II promoter
activation of MAPK activity
transcription from RNA polymerase II promoter
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
cell cycle arrest
response to X-ray
response to organonitrogen compound
response to gamma radiation
mitotic G1 DNA damage checkpoint
cellular response to UV
response to drug
negative regulation of JUN kinase activity
transcription, DNA-templated
cell cycle
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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