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Invitrogen

Phospho-PKD1/2/3/PKC mu (Ser738, Ser742) Polyclonal Antibody

View all (5) PKD1/2/3/PKC mu antibodies

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Phospho-PKD1/2/3/PKC mu (Ser738, Ser742) Polyclonal Antibody

Product Details

PA5-104996

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PRKD1(Accession Q15139), corresponding to amino acid residues around phosphorylated Ser738.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816469

Product Specific Information

Antibody detects endogenous levels of PKD1/2/3/PKC mu only when phosphorylated at Serine 738+Serine 742.

Target Information

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: nPKC-D1; nPKC-D2; nPKC-mu; nPKC-nu; PKD2; Protein kinase C mu type; Protein kinase C nu type; protein kinase C, mu; protein kinase C, nu; Protein kinase D; Protein kinase EPK2; Serine/threonine-protein kinase D1; Serine/threonine-protein kinase D2; Serine/threonine-protein kinase D3; unnamed protein product

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Gene Aliases: 4930557O20Rik; 5730497N19Rik; AI325941; CHDED; EPK2; HSPC187; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-NU; PKC-MU; PKC-NU; PKCM; Pkcnu; PKD; PKD1; PKD2; PKD3; PRKCM; PRKCN; PRKD1; PRKD2; PRKD3; RGD1308054

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UniProt ID: (Human) Q15139, (Human) Q9BZL6, (Human) O94806, (Mouse) Q62101, (Rat) Q9WTQ1, (Rat) Q5XIS9, (Mouse) Q8BZ03, (Mouse) Q8K1Y2

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Entrez Gene ID: (Human) 5587, (Human) 25865, (Human) 23683, (Mouse) 18760, (Rat) 85421, (Rat) 292658, (Mouse) 101540, (Rat) 313834, (Mouse) 75292

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein kinase C binding protein binding ATP binding zinc ion binding kinase activity transferase activity heat shock protein binding identical protein binding metal ion binding protein serine kinase activity phosphatidylinositol 3-kinase activator activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
angiogenesis positive regulation of endothelial cell proliferation immune system process apoptotic process inflammatory response Golgi organization signal transduction phospholipase C-activating G-protein coupled receptor signaling pathway integrin-mediated signaling pathway nervous system development positive regulation of autophagy positive regulation of endothelial cell migration positive regulation of gene expression regulation of keratinocyte proliferation positive regulation of neuron projection development regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril sphingolipid biosynthetic process cell differentiation cellular response to amino acid starvation cellular response to oxidative stress intracellular signal transduction cellular response to vascular endothelial growth factor stimulus positive regulation of protein import into nucleus positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of blood vessel endothelial cell migration cell-cell adhesion mediated by cadherin innate immune response positive regulation of osteoblast differentiation positive regulation of angiogenesis positive regulation of cell size negative regulation of endocytosis positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation positive regulation of protein export from nucleus vascular endothelial growth factor receptor signaling pathway Golgi vesicle transport defense response to Gram-negative bacterium positive regulation of NF-kappaB transcription factor activity regulation of release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling positive regulation of sarcomere organization transepithelial transport cellular response to hydroperoxide response to norepinephrine cellular response to norepinephrine stimulus positive regulation of peptide hormone secretion positive regulation of NLRP3 inflammasome complex assembly cellular response to angiotensin cellular response to phorbol 13-acetate 12-myristate cellular response to endothelin positive regulation of endothelial cell chemotaxis regulation of integrin-mediated signaling pathway adaptive immune response protein phosphorylation cell adhesion positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of interleukin-2 production positive regulation of interleukin-8 production positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of cell adhesion T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway positive regulation of sequence-specific DNA binding transcription factor activity endothelial tube morphogenesis regulation of T cell apoptotic process positive regulation of ERK1 and ERK2 cascade positive regulation of DNA biosynthetic process phosphorylation peptidyl-serine phosphorylation positive regulation of CREB transcription factor activity positive regulation of peptidyl-serine phosphorylation positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway negative regulation of cell death protein kinase D signaling positive regulation of histone deacetylase activity cell death positive regulation of intracellular signal transduction mitophagy in response to mitochondrial depolarization
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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