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Invitrogen

Phospho-CD32 (Tyr288) Polyclonal Antibody

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Phospho-CD32 (Tyr288) Polyclonal Antibody

Product Details

PA5-105099

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human FCGR2A(Accession P12318), corresponding to amino acid residues around phosphorylated Tyr288.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816572

Product Specific Information

Antibody detects endogenous levels of CD32 only when phosphorylated at Tyr288.

Target Information

This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD16; CD32; CD32 receptor 2; CD32 receptor 2a; CDw32; Fc fragment of IgG low affinity IIa receptor for (CD32); Fc fragment of IgG receptor IIa; Fc fragment of IgG receptor IIb; Fc fragment of IgG receptor IIc; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity IIc, receptor for (CD32); Fc gamma receptor IIC; Fc gamma receptor RIIa3; Fc gamma RIIb; Fc receptor, IgG, low affinity IIb; Fc receptor, IgG, low affinity III; FC-gamma RII; Fc-gamma RII-a; Fc-gamma RII-b; Fc-gamma RII-c; Fc-gamma RIII; Fc-gamma-RIIa; Fc-gamma-RIIb; Fc-gamma-RIIc; FCGR2B; FcgRIIa3 splice variant; FcRII; fcRII-a; fcRII-b; FcRIII; FGFR2B; IgG Fc fragment receptor; IgG Fc fragment receptor precursor; IgG Fc receptor alpha-Fc-gamma-RII; IgG Fc receptor beta-Fc-gamma-RII; IgG Fc receptor II beta; IgG Fc receptor II-a; IgG Fc receptor II-b; IgG Fc receptor II-c; IgG Fc receptor III; IgG Fc receptor precursor; Immunoglobulin G Fc receptor II; immunoglobulin G Fc receptor II-c; Low affinity immunoglobulin gamma Fc region receptor II; Low affinity immunoglobulin gamma Fc region receptor II-a; Low affinity immunoglobulin gamma Fc region receptor II-b; Low affinity immunoglobulin gamma Fc region receptor II-c; Low affinity immunoglobulin gamma Fc region receptor III; MGC23887; MGC30032; RP11-5K23.6; unnamed protein product

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Gene Aliases: CD32; CD32A; CD32B; CD32C; CDW32; FCG2; FcgammaRIIa; FcgammaRIIb; FcgammaRIIB2; FcgammaRIIc; FcGR; FCGR2; FCGR2A; FCGR2A1; FCGR2B; FCGR2C; Fcgr3; Fcgr3a; FcGRIIB; FCRII; FcRII-c; FCRIIC; IGFR2

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UniProt ID: (Human) P12318, (Human) P31994, (Human) P31995, (Rat) P27645, (Rat) Q63203

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Entrez Gene ID: (Human) 2212, (Human) 2213, (Human) 9103, (Rat) 116591, (Rat) 289211

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Function(s)
protein binding IgG receptor activity IgG binding beta-amyloid binding low-affinity IgG receptor activity macromolecular complex binding transmembrane signaling receptor activity immunoglobulin binding immunoglobulin receptor superfamily
Process(es)
antibody-dependent cellular cytotoxicity immune system process cell surface receptor signaling pathway positive regulation of tumor necrosis factor production Fc-gamma receptor signaling pathway positive regulation of phagocytosis negative regulation of type I hypersensitivity negative regulation of antibody-dependent cellular cytotoxicity negative regulation of cytokine production immune effector process follicular dendritic cell activation mature B cell differentiation involved in immune response follicular B cell differentiation immune complex clearance by monocytes and macrophages negative regulation of dendritic cell antigen processing and presentation regulation of B cell antigen processing and presentation negative regulation of immunoglobulin production regulation of immune system process regulation of adaptive immune response negative regulation of acute inflammatory response to antigenic stimulus positive regulation of humoral immune response negative regulation of humoral immune response mediated by circulating immunoglobulin receptor-mediated endocytosis phagocytosis phagocytosis, engulfment defense response inflammatory response response to bacterium immunoglobulin mediated immune response antigen processing and presentation of exogenous peptide antigen via MHC class II cerebellum development negative regulation of B cell proliferation negative regulation of interleukin-10 production negative regulation of macrophage activation negative regulation of cytotoxic T cell degranulation regulation of innate immune response mast cell activation positive regulation of JNK cascade negative regulation of phagocytosis negative regulation of immune response negative regulation of B cell receptor signaling pathway negative regulation of B cell activation cellular response to molecule of bacterial origin regulation of immune complex clearance by monocytes and macrophages negative regulation of neutrophil activation regulation of dendritic spine maintenance regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway cellular response to beta-amyloid positive regulation of response to endoplasmic reticulum stress negative regulation of dendritic cell differentiation immune response nerve development immune complex clearance negative regulation of inflammatory response to antigenic stimulus response to estradiol endocytic recycling negative regulation of neutrophil apoptotic process cellular response to lipopolysaccharide
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