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Invitrogen
Phospho-Annexin A4 (Tyr255) Polyclonal Antibody
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FIGURE: 1 / 3
Phospho-Annexin A4 (Tyr255) Antibody (PA5-105361) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-Annexin A4 (Tyr255) in human kidney tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-Annexin A4 (Tyr255) polyclonal antibody (Product # PA5-105361) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-105361
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ANXA4(Accession P09525), corresponding to amino acid residues around phosphorylated Tyr255.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of Annexin IV only when phosphorylated at Tyr255.
Target Information
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 35-beta calcimedin; Annexin A4; Annexin IV; annexin IV (placental anticoagulant protein II); Annexin-4; ANXA 4; ANXA4; Carbohydrate-binding protein p33/p41; Chromobindin-4; Endonexin I; epididymis secretory protein Li 274; Lipocortin IV; P32.5; PAP-II; Placental anticoagulant protein II; PP4-X; proliferation-inducing gene 28; proliferation-inducing protein 28; Protein II; unnamed protein product
Gene Aliases: AI265406; AIV; ANX4; ANXA4; AW106930; HEL-S-274; P32.5; PAP-II; PIG28; PP4-X; Xanx-4; ZAP36
UniProt ID: (Human) P09525, (Mouse) P97429
Entrez Gene ID: (Human) 307, (Mouse) 11746
negative regulation of transcription from RNA polymerase II promoter
signal transduction
Notch signaling pathway
negative regulation of tumor necrosis factor-mediated signaling pathway
epithelial cell differentiation
negative regulation of interleukin-8 production
negative regulation of apoptotic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
kidney development
regulation of transcription from RNA polymerase II promoter
negative regulation of NF-kappaB transcription factor activity
negative regulation of interleukin-8 secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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