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Invitrogen

Phospho-TrkA (Tyr496) Polyclonal Antibody

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Phospho-TrkA (Tyr496) Polyclonal Antibody

Product Details

PA5-105455

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NTRK1(Accession P04629), corresponding to amino acid residues around phosphorylated Tyr496.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816883

Product Specific Information

Antibody detects endogenous levels of TrkA only when phosphorylated at Tyr496.

Target Information

NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp781I14186; EC 2.7.10.1; gp140trk; High affinity nerve growth factor receptor; kinase TrkA; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; Oncogene TRK; p140-TrkA; trk tyrosine-specific protein kinase; Trk-A; TRK1-transforming tyrosine kinase protein; tropomyosin receptor kinase A; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; unnamed protein product

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Gene Aliases: MTC; NTRK1; p140-TrkA; TRK; Trk-A; TRK1; TRKA

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UniProt ID: (Human) P04629

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Entrez Gene ID: (Human) 4914

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin receptor activity neurotrophin p75 receptor binding protein binding ATP binding nerve growth factor receptor activity kinase activity transferase activity kinase binding identical protein binding protein homodimerization activity neurotrophin binding nerve growth factor binding
Process(es)
protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway spermatogenesis nervous system development axon guidance learning or memory circadian rhythm negative regulation of cell proliferation response to xenobiotic stimulus programmed cell death involved in cell development positive regulation of neuron projection development peptidyl-tyrosine phosphorylation olfactory nerve development cell differentiation B cell differentiation neuron projection development response to nutrient levels response to nicotine peptidyl-tyrosine autophosphorylation nerve growth factor signaling pathway mechanoreceptor differentiation negative regulation of apoptotic process positive regulation of programmed cell death negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of angiogenesis positive regulation of Ras protein signal transduction protein autophosphorylation neurotrophin TRK receptor signaling pathway ephrin receptor signaling pathway sympathetic nervous system development neuron development response to axon injury detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain positive regulation of NF-kappaB transcription factor activity neuron apoptotic process response to hydrostatic pressure response to electrical stimulus positive regulation of protein kinase B signaling positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic Sertoli cell development innervation axonogenesis involved in innervation behavioral response to formalin induced pain positive regulation of ERK1 and ERK2 cascade cellular response to nicotine cellular response to growth factor stimulus cellular response to beta-amyloid cellular response to nerve growth factor stimulus
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