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Invitrogen

Phospho-Cdc42 (Tyr64) Polyclonal Antibody

View all (19) CDC42 antibodies

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Phospho-Cdc42 (Tyr64) Polyclonal Antibody

Product Details

PA5-105596

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CDC42(Accession P60953), corresponding to amino acid residues around phosphorylated Tyr64.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817024

Product Specific Information

Antibody detects endogenous levels of Rac1/cdc42 only when phosphorylated at Tyr64.

Target Information

Rac1 is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for the Rac1 gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein); cell division cycle 42 homolog; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)); G25K GTP-binding protein; growth-regulating protein; GTP binding protein, 25kDa; GTP-binding protein; GTP-binding protein G25K; RP1-224A6.5; small GTP binding protein; small GTP binding protein CDC42; unnamed protein product

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Gene Aliases: AI747189; AU018915; CDC42; CDC42Hs; G25K; TKS

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UniProt ID: (Human) P60953, (Rat) Q8CFN2, (Mouse) P60766

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Entrez Gene ID: (Human) 998, (Rat) 64465, (Mouse) 12540

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Function(s)
nucleotide binding GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding hydrolase activity protein kinase binding GTP-dependent protein binding thioesterase binding GBD domain binding apolipoprotein A-I receptor binding identical protein binding ubiquitin protein ligase activity mitogen-activated protein kinase kinase kinase binding small GTPase
Process(es)
heart process cardiac conduction system development cardiac neural crest cell migration involved in outflow tract morphogenesis endocytosis phagocytosis, engulfment actin filament organization Golgi organization regulation of mitotic nuclear division nuclear migration establishment or maintenance of cell polarity signal transduction integrin-mediated signaling pathway small GTPase mediated signal transduction nervous system development protein localization anatomical structure morphogenesis regulation of lamellipodium assembly positive regulation of lamellipodium assembly substantia nigra development establishment of cell polarity actin cytoskeleton organization cell differentiation macrophage differentiation positive regulation of cell growth positive regulation of cell migration positive regulation of pseudopodium assembly negative regulation of protein complex assembly positive regulation of cytokinesis regulation of actin cytoskeleton organization cell junction assembly adherens junction organization embryonic heart tube development establishment or maintenance of apical/basal cell polarity dendritic cell migration neuropilin signaling pathway positive regulation of MAPK cascade modulation by host of viral process establishment of epithelial cell apical/basal polarity filopodium assembly positive regulation of pinocytosis neuron fate determination positive regulation of cellular component organization regulation of filopodium assembly positive regulation of filopodium assembly regulation of stress fiber assembly positive regulation of stress fiber assembly nucleus localization establishment of localization in cell establishment of Golgi localization positive regulation of protein kinase B signaling regulation of attachment of spindle microtubules to kinetochore heart contraction Wnt signaling pathway, planar cell polarity pathway positive regulation of epithelial cell proliferation involved in lung morphogenesis dendritic spine morphogenesis cellular response to interferon-gamma organelle transport along microtubule endothelin receptor signaling pathway involved in heart process regulation of postsynapse organization positive regulation of substrate adhesion-dependent cell spreading positive regulation of protein phosphorylation sprouting angiogenesis keratinocyte development metabolic process response to glucose positive regulation of gene expression negative regulation of gene expression single organismal cell-cell adhesion regulation of exocytosis hair follicle morphogenesis keratinization regulation of protein stability positive regulation of peptidyl-serine phosphorylation cellular protein localization multicellular organism growth regulation of protein catabolic process positive regulation of catalytic activity regulation of protein heterodimerization activity positive regulation of neuron apoptotic process positive regulation of phosphatidylinositol 3-kinase activity positive regulation of DNA replication regulation of protein kinase activity positive regulation of JNK cascade epidermis morphogenesis actin filament bundle assembly regulation of protein metabolic process positive regulation of synapse structural plasticity canonical Wnt signaling pathway submandibular salivary gland formation epithelial-mesenchymal cell signaling hair follicle placode formation positive regulation of hair follicle cell proliferation actin filament branching epithelial cell-cell adhesion positive regulation of intracellular protein transport Rho protein signal transduction endosomal transport
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