Search

  • Fale Conosco
  • Pedido rápido

Invitrogen

Phospho-CaMKII alpha/beta/delta (Ser235) Polyclonal Antibody

View all (6) CaMKII alpha/beta/delta antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Phospho-CaMKII alpha/beta/delta (Ser235) Polyclonal Antibody

Product Details

PA5-105641

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CAMK2B(Accession Q13554), corresponding to amino acid residues around phosphorylated Ser235.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817069

Product Specific Information

Antibody detects endogenous levels of CaMKII only when phosphorylated at Ser235.

Target Information

The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be co-expressed in the same tissue type. CaMKII alpha is autophosphorylated on Thr 286 upon the binding of the Ca2+/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+/CaM trapping, which is thought to be involved in the synaptic encoding of information.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: alpha CaM kinase II; alpha-CaMKII; alternatively spliced; Ca++/calmodulin-dependent protein kinase 2 delta subunit; Ca++/calmodulin-dependent protein kinase II beta subunit; Ca++/calmodulin-dependent protein kinase II delta subunit; Ca++/calmodulin-dependent protein kinase II, delta subunit; Ca2+/calmodulin-dependent protein kinase II alpha; Calci; Calcium, calmodulin-dependent protein kinase II; Calcium, calmodulin-dependent protein kinase, type II; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase II alpha subunit; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II beta chain; calcium/calmodulin-dependent protein kinase type II delta chain; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type II subunit beta; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II; CaM kinase II alpha subunit; CaM kinase II beta subunit; CaM kinase II delta subunit; CaM kinase II subunit alpha; CaM kinase II subunit beta; CaM kinase II subunit delta; CaM-kinase II alpha chain; CaM-kinase II beta chain; CaM-kinase II delta chain; CAMK; CaMK II; CaMK-2 delta; CaMK-2a; CAMK-II; CaMK-II alpha subunit; CaMK-II delta subunit; caMK-II subunit alpha; caMK-II subunit beta; caMK-II subunit delta; CaMK2 delta; CaMK2- delta; CaMK2-a; CAMK2G; CAMKG; proline rich calmodulin-dependent protein kinase; protein kinase homolog; unnamed protein product

View more View less

Gene Aliases: 2810011D23Rik; 8030469K03Rik; [d]-CaMKII; CAM2; CaMK II; CAMK1; CAMK2; CAMK2A; CAMK2B; CAMK2D; CAMKA; CAMKB; CAMKD; Camki; CaMKII; CaMKIIalpha; CaMKIIbeta; CaMKIINalpha; Ck2b; KIAA0968; Kiaa4163; mKIAA0968; MRD53; MRD54; MRT63; PK2CDD; PKCCD; R74975; RATCAMKI

View more View less

UniProt ID: (Human) Q9UQM7, (Human) Q13554, (Human) Q13557, (Mouse) P11798, (Rat) P11275, (Rat) P08413, (Mouse) P28652, (Rat) P15791, (Mouse) Q6PHZ2

View more View less

Entrez Gene ID: (Human) 815, (Human) 816, (Human) 817, (Mouse) 12322, (Rat) 25400, (Rat) 24245, (Mouse) 12323, (Rat) 24246, (Mouse) 108058

View more View less

Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity protein binding calmodulin binding ATP binding kinase activity transferase activity glutamate receptor binding identical protein binding protein homodimerization activity metal ion binding protein serine kinase activity actin binding sodium channel inhibitor activity titin binding ion channel binding transferase activity, transferring phosphorus-containing groups GTPase activating protein binding phospholipase binding nitric-oxide synthase binding non-receptor serine/threonine protein kinase
Process(es)
G1/S transition of mitotic cell cycle response to ischemia protein phosphorylation calcium ion transport JAK-STAT cascade positive regulation of cardiac muscle cell apoptotic process cellular response to interferon-beta angiotensin-activated signaling pathway positive regulation of JAK-STAT cascade regulation of neurotransmitter secretion regulation of neuronal synaptic plasticity positive regulation of NF-kappaB transcription factor activity negative regulation of hydrolase activity positive regulation of calcium ion transport long-term synaptic potentiation dendritic spine development cellular response to interferon-gamma regulation of mitochondrial membrane permeability involved in apoptotic process regulation of protein localization to plasma membrane peptidyl-threonine autophosphorylation regulation of endocannabinoid signaling pathway regulation of neuron migration signal transduction nervous system development positive regulation of neuron projection development regulation of skeletal muscle adaptation cell differentiation protein autophosphorylation regulation of long-term neuronal synaptic plasticity regulation of synapse structural plasticity regulation of calcium ion transport regulation of dendritic spine development positive regulation of dendritic spine morphogenesis positive regulation of synapse maturation regulation of cell growth regulation of the force of heart contraction regulation of membrane depolarization regulation of transcription from RNA polymerase II promoter regulation of heart contraction positive regulation of cardiac muscle hypertrophy regulation of cell communication by electrical coupling regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion endoplasmic reticulum calcium ion homeostasis relaxation of cardiac muscle regulation of ryanodine-sensitive calcium-release channel activity regulation of cellular localization cellular response to calcium ion cardiac muscle cell contraction regulation of heart rate by cardiac conduction regulation of cardiac muscle cell action potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of cell communication by electrical coupling involved in cardiac conduction regulation of relaxation of cardiac muscle negative regulation of sodium ion transmembrane transport regulation of calcium ion transmembrane transport via high voltage-gated calcium channel phosphorylation peptidyl-serine phosphorylation ionotropic glutamate receptor signaling pathway inhibitory G-protein coupled receptor phosphorylation regulation of synaptic transmission, cholinergic positive regulation of phospholipase A2 activity response to cadmium ion cell projection morphogenesis neuromuscular process controlling balance activation of meiosis involved in egg activation positive regulation of apoptotic signaling pathway response to hypoxia regulation of sodium ion transport regulation of G2/M transition of mitotic cell cycle positive regulation of smooth muscle cell migration peptidyl-threonine phosphorylation cellular potassium ion homeostasis positive regulation of Rac protein signal transduction positive regulation of smooth muscle cell proliferation protein oligomerization cardiac muscle contraction cell growth involved in cardiac muscle cell development positive regulation of ERK1 and ERK2 cascade negative regulation of sodium ion transmembrane transporter activity
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support