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Phospho-Beclin 1 (Ser90, Ser93, Ser96) Polyclonal Antibody

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Phospho-Beclin 1 (Ser90, Ser93, Ser96) Polyclonal Antibody

Product Details

PA5-105647

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human BECN1(Accession Q14457), corresponding to amino acid residues around phosphorylated Ser90.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817075

Product Specific Information

Antibody detects endogenous levels of Beclin 1 only when phosphorylated at Ser90/93/96.

Target Information

Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: APG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein; Bcl-2-interacting protein beclin; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; Beclin-1; beclin1-beta; beclin1-gamma; Coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; partial ORF; putative; Protein GT197; testis secretory sperm-binding protein Li 215e; unnamed protein product

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Gene Aliases: 4921513J16Rik; 5430417M23Rik; ATG6; beclin1; BECN1; GT197; VPS30

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UniProt ID: (Human) Q14457, (Rat) Q91XJ1, (Mouse) O88597

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Entrez Gene ID: (Human) 8678, (Rat) 114558, (Mouse) 56208

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Function(s)
protein binding protein kinase binding protein binding, bridging ubiquitin protein ligase binding identical protein binding phosphatidylinositol 3-kinase binding GTPase binding binding, bridging molecular_function protease inhibitor
Process(es)
autophagosome assembly mitophagy response to hypoxia cytoplasmic pattern recognition receptor signaling pathway protein targeting to lysosome endocytosis autophagy apoptotic process cellular defense response cellular response to nitrogen starvation lysosome organization mitotic metaphase plate congression JNK cascade circadian rhythm negative regulation of cell proliferation response to xenobiotic stimulus response to iron(II) ion response to lead ion regulation of autophagy negative regulation of autophagy positive regulation of autophagy positive regulation of cardiac muscle hypertrophy macroautophagy regulation of macroautophagy response to nutrient levels regulation of cytokinesis receptor catabolic process response to vitamin E cellular response to amino acid starvation phosphatidylinositol-3-phosphate biosynthetic process p38MAPK cascade cellular response to glucose starvation negative regulation of apoptotic process negative regulation of programmed cell death engulfment of apoptotic cell early endosome to late endosome transport late endosome to vacuole transport neuron development beta-amyloid metabolic process cell division defense response to virus response to other organism positive regulation of protein kinase B signaling SMAD protein signal transduction positive regulation of stress granule assembly protein-containing complex assembly cellular response to hydrogen peroxide cellular response to aluminum ion cellular response to copper ion cellular response to epidermal growth factor stimulus cellular response to oxygen-glucose deprivation autophagosome maturation response to mitochondrial depolarisation positive regulation of attachment of mitotic spindle microtubules to kinetochore negative regulation of autophagosome assembly negative regulation of lysosome organization positive regulation of autophagosome assembly positive regulation of intrinsic apoptotic signaling pathway mitophagy positive regulation of macroautophagy CVT pathway response to drug nucleophagy regulation of catalytic activity negative regulation of cell death positive regulation of mitophagy cytokinesis angiogenesis cell cycle mitophagy in response to mitochondrial depolarization negative regulation of reactive oxygen species metabolic process
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