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Invitrogen

Phospho-JAK3 (Tyr904) Polyclonal Antibody

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Phospho-JAK3 (Tyr904) Polyclonal Antibody

Product Details

PA5-105891

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human JAK3(Accession P52333), corresponding to amino acid residues around phosphorylated Tyr904.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817290

Product Specific Information

Antibody detects endogenous levels of JAK3 only when phosphorylated at Tyr904.

Target Information

Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 may be required for complex responses. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Breast-JAK3; JAK-3; JAK3B; Janus kinase 3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); Janus kinase 3 protein-tyrosine kinase; Janus kinase 3, protein-tyrosine kinase; L JAK; L-JAK; Leukocyte janus kinase; Tyrosine-protein kinase JAK3; unnamed protein product

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Gene Aliases: fae; JAK-3; JAK3; JAK3_HUMAN; JAKL; L-JAK; LJAK; RATJAK3; wil

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UniProt ID: (Human) P52333, (Mouse) Q62137, (Rat) Q63272

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Entrez Gene ID: (Human) 3718, (Mouse) 16453, (Rat) 25326

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity growth hormone receptor binding protein binding ATP binding kinase activity transferase activity protein phosphatase binding transferase activity, transferring phosphorus-containing groups hormone receptor binding transcription factor binding
Process(es)
adaptive immune response immune system process negative regulation of dendritic cell cytokine production enzyme linked receptor protein signaling pathway JAK-STAT cascade tyrosine phosphorylation of STAT protein negative regulation of glycoprotein biosynthetic process cytokine-mediated signaling pathway cell differentiation B cell differentiation negative regulation of interleukin-10 production negative regulation of interleukin-12 production intracellular signal transduction interleukin-15-mediated signaling pathway interleukin-4-mediated signaling pathway interleukin-2-mediated signaling pathway interleukin-7-mediated signaling pathway interleukin-9-mediated signaling pathway regulation of apoptotic process T cell homeostasis innate immune response negative regulation of T-helper 1 cell differentiation regulation of JAK-STAT cascade regulation of alpha-beta T cell activation negative regulation of T cell activation JAK-STAT cascade involved in growth hormone signaling pathway regulation of T cell apoptotic process negative regulation of thymocyte apoptotic process response to interleukin-2 response to interleukin-4 response to interleukin-15 response to interleukin-9 regulation of leukocyte cell-cell adhesion negative regulation of T-helper 17 cell lineage commitment protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cytosolic calcium ion concentration phosphorylation cell migration peptidyl-tyrosine phosphorylation erythrocyte differentiation peptidyl-tyrosine autophosphorylation positive regulation of T cell proliferation positive regulation of activated T cell proliferation tyrosine phosphorylation of Stat5 protein negative regulation of FasL biosynthetic process positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation lymph node development positive regulation of immune response positive regulation of calcium ion transport positive regulation of dendritic cell apoptotic process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand inflammatory response
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